혜화의학회지 (Journal of Haehwa Medicine)
- 제8권1호
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- Pages.403-424
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- 1999
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- 2586-3002(pISSN)
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- 2586-3347(eISSN)
가미사삼맥문동탕(加味沙蔘麥門冬湯)이 항암활성(抗癌活性)과 방사선부작용(放射線副作用) 억제효과(抑制效果)에 미치는 영향(影響)
Study on Antitumor Activity and Radioprotective effects of Kamisasammaekmundongtang
- Park, Yang-chun (Division of Respiratory, Department of Internal Medicine, College of Oriental Medicine, Taejon University) ;
- Kim, Byeong-tak (Division of Respiratory, Department of Internal Medicine, College of Oriental Medicine, Taejon University)
- 발행 : 1999.09.01
초록
To evaluate the antitumor activity, antimetastatic and radioprotective effects of Kamisasammaekmundongtang(KSMT), studies were done experimentally. The results were obtained as follows: 1. In cytotoxicity against P388, A549 and B16-F10, KSMT was not showed satisfiable cytotoxicity as compared with control. 2. In Inhibitory effect on activity of DNA topoisomerase I, KSMT has strong inhibitory effect. 3. The inhibitory effect on adhesion of A549 to complex extracellular matrix was significantly increased at 0.5mg/ml, 1mg/ml of KSMT. 4. The T/C% was 122 in KSMT treated group in S-180 bearing ICR mice. 5. In antiangiogenetic effect on CAM assay, inhibitory rate was 33% in KSMT treated group. 6. In pulmonary colonization assay, a number of colonies in the lungs were decreased significantly in KSMT treated group as compared with control group. 7. By FACS analysis of splenic leukocyte after exposure to radiation by linear accelerator, T-helper cell, B cell and macrophage in KSMT treated group were significantly increased while splenocytes were decreased in control group. 8. In histological changes of jejunum of