Effect on Aluminum and Silicon in Peptic Ulcer Patients

소화성 궤양 환자의 혈중 및 요중 aluminum과 silicon

  • Shin, Hae-Rim (Department of Preventive Medicine, College of Medicine, and Industrial Medicine Research Institute, Dong-A University) ;
  • Kim, Jung-Il (Department of Preventive Medicine, College of Medicine, and Industrial Medicine Research Institute, Dong-A University) ;
  • Kim, Doo-Hee (Department of Preventive Medicine, Dongguk University College of Medicine) ;
  • Choi, Suk-Ryol (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Seoh, Jung-Il (Department of Internal Medicine. Dongguk University College of Medicine) ;
  • Roberts, Norman B. (Department of Clinical Pathology, Liverpool University Hospital, UK) ;
  • Kim, Joon-Youn (Department of Preventive Medicine, College of Medicine, and Industrial Medicine Research Institute, Dong-A University)
  • 신해림 (동아대학교 의과대학 예방의학교실 및 산업의학연구소) ;
  • 김정일 (동아대학교 의과대학 예방의학교실 및 산업의학연구소) ;
  • 김두희 (동국대학교 의과대학 예방의학교실) ;
  • 최석렬 (동아대학교 의과대학 내과학교실) ;
  • 서정일 (동국대학교 의과대학 내과학교실) ;
  • ;
  • 김준연 (동아대학교 의과대학 예방의학교실 및 산업의학연구소)
  • Published : 1999.06.01

Abstract

Objectives: This study was carried out to investigate the aluminum concentrations in blood, urine and drinking water, the factors which affect the concentrations and the role of silicon in patients who were taking antacid containing aluminum. Methods: We selected 122 peptic ulcer patients as cases and 144 healthy examinees as controls. Blood, urine, and drinking water were collected from the each study subject and we measured aluminum concentrations as well as silicon concentrations in the specimens. The factors including silicon affect on the aluminum concentrations were also analyzed, Results: 1. The mean duration of antacid administration was 12 months, and the mean daily and total amount of aluminum administration were 0.9 g and 304 g per each patient, respectively. 2. The blood and urine aluminum concentrations were significantly higher in the case. 3. The blood silicon concentration was significantly lower in the control group, and the urine silicon concentration was significantly higher in the case. 4. Urine aluminum concentration was significantly correlated with blood aluminum concentration (r=0.18), and urine silicon concentration was correlated with blood aluminum (r=0.19) and urine aluminum concentrations (r=0.13). 5. The longer the duration of antacid administration and the larger the total and daily amount of aluminum in the antacid were, the higher urine aluminum and silicon concentrations were, but not to a statistically significant degree. Conclusions: Blood and urine aluminum concentrations were higher in the ulcer patients. The authors suggest that follow-up studies of the patients who administered antacid with high aluminum content for long duration should be done.

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