Acknowledgement
Supported by : 한국과학재단
Korean Journal of Veterinary Research (대한수의학회지)
- Volume 39 Issue 3
- /
- Pages.435-447
- /
- 1999
- /
- 2466-1384(pISSN)
- /
- 2466-1392(eISSN)
Localizations of substance P, CGRP and calcium binding proteins in Korean native goat duodenum
한국재래산양 십이지장의 장관신경계통에 분포하는 Substance P, CGRP 및 칼슘결합단백질 반응세포에 대한 면역조직화학적 연구
- Lee, In-se (College of Veterinary Medicine, Seoul National University) ;
-
Lee, Heungshik S.
(College of Veterinary Medicine, Seoul National University)
;
- Song, Seung-hoon (College of Veterinary Medicine, Seoul National University) ;
- Yoon, Sung-tae (College of Veterinary Medicine, Seoul National University) ;
- Hwang, In-koo (College of Veterinary Medicine, Seoul National University) ;
-
Kang, Tae-cheon
(College of Medicine, Hallym University)
;
-
Won, Moo-ho
(College of Medicine, Hallym University)
;
- Seo, Je-hoon (College of Medicine, Seoul National University)
- 이인세 (서울대학교 수의과대학) ;
-
이흥식
(서울대학교 수의과대학)
;
- 송승훈 (서울대학교 수의과대학) ;
- 윤성태 (서울대학교 수의과대학) ;
- 황인구 (서울대학교 수의과대학) ;
-
강태천
(한림대학교 의과대학)
;
-
원무호
(한림대학교 의과대학)
;
- 서제훈 (서울대학교 의과대학)
- Received : 1999.03.18
- Published : 1999.06.22
Abstract
The localization of substance P(SP), calcitonin gene-related peptide(CGRP) and three calcium binding proteins, calbindin D-28k(CB), calretinin(CR) and parvalbumin(PA) was immunohistochemically examined in the myenteric and submucous plexuses of Korean native goat duodenum. In the neurons of myenteric and submucous plexuses of duodenum, immunoreactivities of SP, CGRP and CB were confirmed in both nerve cell bodies and fibers. In contrast, CR immunoreactivity was found only in nerve fibers of myenteric plexuses, while PA immunoreactivity was found only in nerve cell bodies of submucous plexuses. In the inner circular muscle layer, dense SP-like immunoreactive fibers were prominent but only a few CGRP-like immunoreactivities were observed. Most of SP- and CGRP-like immunoreactive neurons of both plexuses colocalized with CB. This result showed that SP and CGRP may have a important role for the movement of small intestine. The colocalizations of CB with SP or CGRP in myenteric and submucous plexuses suggest that CB may serve neuromodulatory role for SP- and CGRP-immunoreacted neurons on the movement of intestinal wall.