한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)
- 제16권4호
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- Pages.299-306
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- 1999
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- 1225-9098(pISSN)
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- 2288-1069(eISSN)
DOI QR Code
항진균제로서 무화과 활성물질을 이용한 Ketoconazole 유도체 합성
The Synthesis of Ketoconazole Derivatives Using Biological Activity Compounds in Figue as an Antifungal Agents
초록
For the synthesis of new antifungal agents, We have synthesized four new ketoconazole derivatives were synthesized by the reaction of cis-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-1,3-dioxolan-4-yl]methane sulfonate with isolated fig compounds. These compounds were showed strong antifungal activity against C, albicans ATCC 10231. C, utilis. S, cerevisiae ATCC 9763. A and niger ATCC 9029. Among them, sample No.(13) showed potent inhibition activity. Generally, other samples showed biological activity in vitro test. The above results showed the possibility of the development of new antifungal agents.