Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)
- Volume 16 Issue 4
- /
- Pages.293-298
- /
- 1999
- /
- 1225-9098(pISSN)
- /
- 2288-1069(eISSN)
DOI QR Code
Antibiotics Characteristics by Dual action of Sulfonamide Agents In vitro
In vitro에서 Sulfonamide의 Dual Action에 의한 항균특성
- Jung, Duck-Chae (Dept. of Chemistry, University of InChon) ;
- Hwang, Sung-Kyu (Dept. of Chemical Engineering, Myong-Ji Univ.) ;
- Kim, Jong-Woan (Dept. of Chemical Engineering, Myong-Ji Univ.) ;
- Seok, Ji-Hyun (Dept. of Environmental Health, Yong In Univ.) ;
- Kim, Woon-Kyeom (Dept. of Fine chemistry, Seoul National Univ. of Technology)
- Published : 1999.12.31
Abstract
Dual-action agents are unique chemical entities comprised of two different types of antibacterial compounds covalently linked together in a single molecule in such a way that both components are able to exert their bactericidal properties. Crosslinked sulfadiazine-sulfacetamide such as antibiotics synthesized by crosslingking reaction such as glutaraldehyde. These structures of the compounds were confirmed by IR, NMR. 4 strains of Gram(+) and Gram(-) revealed effective susceptibility to synthetic crosslinked sulfadiazine-sulfacetamide.
Keywords