Journal of Periodontal and Implant Science
- 제29권4호
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- Pages.873-893
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- 1999
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
성견 1면 골결손부에서 rhBMP-2/ACS가 치주조직 치유에 미치는 영향
The Effects of rhBMP-2/ACS on the Periodontal Healing of 1-Wall Intrabony Defects in Dogs
- 전혜영 (연세대학교 치과대학 치주과학 교실, 연세대학교 치과대학 치주조직재생연구소) ;
- 조규성 (연세대학교 치과대학 치주과학 교실, 연세대학교 치과대학 치주조직재생연구소) ;
- 김종관 (연세대학교 치과대학 치주과학 교실, 연세대학교 치과대학 치주조직재생연구소) ;
- 채중규 (연세대학교 치과대학 치주과학 교실, 연세대학교 치과대학 치주조직재생연구소)
- Jun, Hye-Young (Department of Periodontology, College of Dentistry, Yonsei Univesity, Research Institute for Periodontal Regeneration) ;
- Cho, Kyoo-Sung (Department of Periodontology, College of Dentistry, Yonsei Univesity, Research Institute for Periodontal Regeneration) ;
- Kim, Chong-Kwan (Department of Periodontology, College of Dentistry, Yonsei Univesity, Research Institute for Periodontal Regeneration) ;
- Chai, Jung-Kiu (Department of Periodontology, College of Dentistry, Yonsei Univesity, Research Institute for Periodontal Regeneration)
- 발행 : 1999.12.31
초록
The ultimate goal of periodontal therapy is the regeneration of periodontal tissue and repair of function. For more than a decade there have been many efforts to develop materials and bioactive molecule(such as growth factor and differentiation factors) to promote periodontal wound healing. Among the bioactive molecules, bone morphogenetic protein(BMP) was studied for periodontal wound healing. Since Urist demonstrated that demineralized bone matrix could induce the formation of cartilage and bone in ectopic site, many studies on BMP have been reported. Among those BMPs, it was reported that rhBMP-2 enhanced the healing of bone defects in animal studies and clinical studies. However, its efficacy in periodontal regeneration, especially 1-wall intrabony defects is still unknown. The purpose of this study was to examine the effect of rhBMP-2/ACS on the epithelial migration, gingival connective tissue adhesion, cementum formation, alveolar bone regeneration in intrabony defects of dogs. Four millimeter deep and four millimeter wide 1-wall defects were surgically created in the mesial aspects of the 3rd incisors. The test group received rhBMP-2/ACS with a flap procedure and the control underwent buffer/ACS with a flap procedure. Histologic analysis after 8 weeks of healing revealed the following results: 1. The length of epithelial growth(the distance from alveolar crest to the apical end of JE) was