Journal of Periodontal and Implant Science
- Volume 29 Issue 4
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- Pages.803-823
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- 1999
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
Effects of Direct Cell Contact Between Monocytes and Fibroblasts on the Interleukin-6 Production and Cell Proliferation of Human Gingival and Peri - odontal Ligament Fibroblasts
치은섬유아세포와 치주인대섬유아세포의 interleukin-6 분비 및 세포성장에 미치는 단핵구세포주와 섬유아세포의 세포간 접촉작용
- Kim, Soo-Ah (Department of Periodontology and Research Institute of Oral Bio-science, College of Dentistry, Chonbuk National University) ;
- Lee, Ho (Department of Periodontology and Research Institute of Oral Bio-science, College of Dentistry, Chonbuk National University) ;
- Kim, Hyung-Seop (Department of Periodontology and Research Institute of Oral Bio-science, College of Dentistry, Chonbuk National University) ;
- Oh, Kwi-Ok (Department of Periodontology and Research Institute of Oral Bio-science, College of Dentistry, Chonbuk National University)
- 김수아 (전북대학교 치과대학 치주과학교실) ;
- 이호 (전북대학교 치과대학 치주과학교실) ;
- 김형섭 (전북대학교 치과대학 치주과학교실) ;
- 오귀옥 (전북대학교 치과대학 치주과학교실)
- Published : 1999.12.31
Abstract
In order to reveal immunopathogenesis of periodontal tissue destruction, it is important to clarify the molecular mechanism of trafficking and retention of activated leukocytes, including monocytes/macrophages. Gingival fibroblasts may be involved in the regulation of inflammatory cell accumulation in the extravascular periodontal connective tissues via cytokine production and surface expression of adhesion molecules. In this study, it was investigated the molecular basis for the adhesive interactions between monocytes and fibroblasts such as peri-odontal ligament fibroblast(PDLF), human gingival fibroblast(HGF), and human dermal fibroblast(HDF). First, it was examined the evidence whether monocyte-fibroblast cell contact may cause signal transduction in fibroblasts. Being directly in contact with fixed human monocyte cell line THP-1, or U937, upregulation of IL-6 production,
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