Journal of Periodontal and Implant Science
- Volume 29 Issue 3
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- Pages.677-693
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- 1999
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
Effect of Tetracycline Analogues on The Activity of Matrix Metalloproteinase-3 in Gingival Fibroblasts
테트라사이클린계 약물이 치은섬유아세포내 MMP-3의 활성도에 미치는 영향
- Cho, Jong-Hee (Department of Periodontology, College of Dentistry, Chosun University) ;
- Kim, Sang-Mok (Department of Periodontology, College of Dentistry, Chosun University) ;
- Kim, Byung-Ock (Department of Periodontology, College of Dentistry, Chosun University) ;
- Han, Kyung-Yoon (Department of Periodontology, College of Dentistry, Chosun University)
- 조종희 (조선대학교 치과대학 치주과학교실) ;
- 김상목 (조선대학교 치과대학 치주과학교실) ;
- 김병옥 (조선대학교 치과대학 치주과학교실) ;
- 한경윤 (조선대학교 치과대학 치주과학교실)
- Published : 1999.09.30
Abstract
Extracellular matrix component is degraded by enzymes of thematrix metalloproteinases(MMPs). MMPs are produced by both hemopoietic and structural cells. Increased activity of MMP-3 in periodontium is strongly associated with inflammatory periodontal disease. The purpose of the present study was to determine the effect of tetracycline analogues on the activity of MMP-3. Tetracycline-HCl, doxycycline-HCl, and minocycline-HCl were applied to huamn gingival fibroblasts at various concentrations of 10, 25, 50, 100, 200
Keywords
- tetracycline analogues;
- Interleukin-$1{\beta}$;
- matrix metalloproteinase-3 human gingival fibroblasts.