The Journal of the Korean Society for Microbiology (대한미생물학회지)

The Korea Society for Microbiology (대한미생물학회)
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Investigation on the Immunity to Pertussis in the Korea

한국에서의 백일해 면역력에 대한 조사 연구

  • Min, Hong-Ki (Department of Pathology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Shin, Kwang-Hoon (Department of Epidiomology, National Institute of Health) ;
  • Kim, Soon-Nam (Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Lee, Myong-Sook (Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Yoo, Si-Hyung (Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Kim, Ji-Yon (Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Kang, Jin-Han (Department of Pediatrics, School of medicine, The Catholic University of Korea)
  • 민홍기 (식품의약품안전청 독성연구소 병리부) ;
  • 신광훈 (국립보건원 감염질환부) ;
  • 김순남 (식품의약품안전청 생물학평가부) ;
  • 이명숙 (식품의약품안전청 생물학평가부) ;
  • 유시형 (식품의약품안전청 생물학평가부) ;
  • 김지윤 (식품의약품안전청 생물학평가부) ;
  • 강진한 (가톨릭대학교 의과대학 소아과)
  • Published : 1999.12.31
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Abstract

Acellular pertussis vaccine has been used widely in Korea since 1984. However, because many of the former generations were not inoculated with pertussis vaccine, they may infect infants with pertussis. With this background, we investigated the prevalence of pertussis antibodies in all age groups. Enzyme-linked immunosorbent assay (ELISA) to assess IgG antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA) and bacterial agglutination (BA) to assess antibodies to agglutinogen were compared on 842 serum samples which were donated from 11 hospitals in Seoul area. In comparison with age groups under 20 years, antibodies of adults against PT and FHA were maintained. But antibodies against agglutinogen showed no pattern in all age groups. Antibodies to PT were correlated with antibodies to FHA. There was no significant difference in antibody levels between male and female (p<0.05).

Keywords

References

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