Journal of Microbiology
- Volume 37 Issue 4
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- Pages.256-262
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- 1999
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- 1225-8873(pISSN)
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- 1976-3794(eISSN)
Deletion Analysis of the Major NF-${\kappa}B$ Activation Domain in Latent Membrane Protein 1 of Epstein-Barr Virus
- Cho, Shin (Department of Biological Science and Institute of Bioscience and Biotechnology Myongji University) ;
- Lee, Won-Keun (Department of Biological Science and Institute of Bio science and Biotechnology Myongji University)
- Published : 1999.01.01
Abstract
Latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) is an integral membrane protein with six transmembrane domains, which is essential for EBV-induced B cell transformation. LMP1 functions as a constitutively active tumor necrosis factor receptor (TNFR) like membrane receptor, whose signaling requires recruitment of TNFR-associated factors (TRAFs) and leads to NF-