대한바이러스학회지 (The Journal of Korean Society of Virology)
- 제29권3호
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- Pages.165-174
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- 1999
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- 1225-2344(pISSN)
Herpes Simplex Virus Type 1 마우스 뇌염모델에서의 조직내 바이러스 증식 및 재활성에 미치는 Acyclovir의 약효
Efficacy of Acyclovir on Virus Replication in Infected Tissues and Virus Reactivation from Explanted Tissues in Mouse Encephalitis Model of Herpes Simplex Virus Type 1
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이종교
(한국화학연구소 의약활성연구실) ;
- 김지현 (한국화학연구소 의약활성연구실) ;
- 배판기 (한국화학연구소 의약활성연구실) ;
- 피미경 (한국화학연구소 의약활성연구실) ;
-
김해수
(한국화학연구소 의약활성연구실)
-
Lee, Chong-Kyo
(Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) ;
- Kim, Jee-Hyun (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) ;
- Bae, Pan-Kee (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) ;
- Pi, Mi-Kyung (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) ;
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Kim, Hae-Soo
(Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology)
- 발행 : 1999.09.30
초록
To investigate viral pathogenesis and in vivo efficacy of acyclovir (ACV) in mouse HSV-1 encephalitis models, female BALB/c mice aged 5 weeks were inoculated with strain F either intranasally (IN) or intracerebrally (IC). ACV-treatment by intraperitomeal injection with 0, 5, 10 and 25 mg/kg b.i.d. for 6 days was commenced 1 h after infection. Body weight and signs of clinical disease were noted daily up to 2 weeks.
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