The Journal of Korean Society of Virology (대한바이러스학회지)
- Volume 29 Issue 4
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- Pages.211-219
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- 1999
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- 1225-2344(pISSN)
Effects of Trehalose, Glucose and Lactose on the Stability of Hantaan Virus Vaccine
트리할로스, 포도당 및 유당이 한탄바이러스 백신의 안정성에 미치는 영향
- Ko, Eun-Joo (Department of Microbiology, Medical College, Korea University, Institute for Viral Diseases, Korea University) ;
- Seong, In-Wha (Department of Microbiology, Medical College, Korea University, Institute for Viral Diseases, Korea University)
- Published : 1999.12.30
Abstract
Most of the currently licensed viral and bacterial vaccines produced in the world are in state of antigen suspension and the immunogenicity of vaccines could be maintained for one or two years only by keeping in the refrigerator, but without refrigeration vaccines would easily lose their immunogenicites. In this study, as a step to develope the method of increasing the stability of vaccines and maintaining the immunogenicity of vaccines for a long time at room temperature or higher temperature, trehalose, glucose and lactose at different concentration were added into the Hantaan virus vaccines and then kept at