농약과학회지 (The Korean Journal of Pesticide Science)
- 제3권1호
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- Pages.29-36
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- 1999
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- 1226-6183(pISSN)
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- 2287-2051(eISSN)
N-Phenyl-O-phenylthionocarbamate 유도체의 항균활성에 미치는 phenyl 치환기의 효과
Phenyl substituent effect on the fungicidal activity of N-Phenyl-O-phenylthionocarbamate derivatives
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Sung, Nack-Do
(Division of Applied Biology & Chemistry, College of Agriculture, Chung-nam National University) ;
- Soung, Min-Gyu (Division of Applied Biology & Chemistry, College of Agriculture, Chung-nam National University)
- 발행 : 1999.05.25
초록
일련의 N-phenyl-O-phenylthionocarbamate 유도체을 합성하고, benomyl 및 metalaxyl 등 2종의 침투성 살균제에 대하여 저항성과 감수성을 나타내는 잿빛곰팡이병균(Botrytis cinerea) 및 고추 역병균(Phytophthora capsici)에 대한 항균활성(obs.
A series of N-phenyl-O-phenylthionocarbamate derivatives were synthesized and determinated fungicidal activities in vitro against gray mold (Botrytis cinerea) and capsicum phytophthora blight (Phytophthora capsici) which showed resistance and sensitivity to benomyl and metalaxyl as systemic fungicides, respectively. The structure-activity relationship (SAR) was investigated by Free-Wilson analysis method and Hansch method. From the basis on the findings, the N-phenyl(X) groups had more contributions than O-phenyl(Y) groups did and ortho-substituents on the N-phenyl group showed high fungicidal activities. Especially, 4-cyano substituent, 2 as X-group showed 50% inhibition(