Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Stabilization of Poly(dA)-[poly(dT)]₂Triplex by Anthryl and Acridine Derivatives: Effect of Side Chains and Nitrogen Atom on the Polycyclic Aromatic Ring

  • Published : 1999.06.20
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Abstract

The effects of anthryl derivatives and 9-aminoacridine on the thermal melting profile of a poly(dA)[poly(dT)]₂triplex were compared 9-Aminoacridine stabilizes the triplex far more effectively than anthryl derivatives. The absorption and CD and LD spectroscopic characteristics of anthryl derivatives are similar to those of 9-aminoacridine when complexed with the triplex; the N atom of acridine, which can act as a hydrogen bond acceptor, plays an important role in triplex stabilization.

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