Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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The Lack of a Direct Effect of Tumor Necrosis Factor-Alpha on Sperm Motility

Tumor Necrosis Factor-Alpha가 정자운동성에 미치는 직접 영향의 부족

  • Song, Eun-Seop (Department of Obstetrics and Gynecology Inha University College of Medicine) ;
  • Lim, Young-Ku (Department of Obstetrics and Gynecology Inha University College of Medicine) ;
  • Song, Yun-Seob (Department of Urology, Soonchunhyong University College of Medicine)
  • 송은섭 (인하대학교 의과대학 산부인과학교실) ;
  • 임영구 (인하대학교 의과대학 산부인과학교실) ;
  • 송윤섭 (순천향대학교 의과대학 비뇨기과학교실)
  • Published : 1999.03.30
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Abstract

Male genital tract inflammatory conditions may be associated with unexplained infertility. The presence of cytokine such as tumor necrosis factor-alpha (TNF-${\alpha}$) was reported in the semen of infertile men. However, the effect of these cytokines on human sperm function is still unclear. The purpose of this study was to investigate the in-vitro effects of TNF-alpha on human sperm motility with computer assisted sperm analysis. Washed sperm from 16 normal men were incubated without and with TNF-${\alpha}$ (0.1, 10, 1000 ng/ml). The changes of parameters of sperm motility were recorded at different time intervals (0, 5, 24 hour). There was no significant change of parameters of sperm motility in the incubation with TNF-${\alpha}$. It is suggested that TNF-${\alpha}$ alone does not interfere with the sperm motility and more studies are needed.

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