Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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A Case of Factor XII Deficiency Which was Found in Recurrent Spontaneous Abortion

반복자연유산 환자에서 발견된 응고인자 12 부족증 1례

  • Nam, Y.S (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
  • Kim, I.H. (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
  • Yoon, T.K. (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
  • Lee, C.N. (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
  • Cha, K.Y. (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University)
  • 남윤성 (포천중문의과대학 산부인과학교실) ;
  • 김인현 (포천중문의과대학 산부인과학교실) ;
  • 윤태기 (포천중문의과대학 산부인과학교실) ;
  • 이정노 (포천중문의과대학 산부인과학교실) ;
  • 차광열 (포천중문의과대학 산부인과학교실)
  • Published : 1999.06.30
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Abstract

Activated factor XII (FXIIc: Hageman factor) is a central component of the contact activation system of blood coagulation, fibrinolysis, and kinin formation. Although patients deficient in FXIIc (up to 50% of normal) do not show increased bleeding tendency, thrombotic complications were reported in 8% to 10% among these patients. The reduced generation of bradykinin resulting in diminished release of tissue plasminogen activator is proposed as a cause of thrombosis in factor XII (FXII)-deficient patients. Similarly, in patients with elevated levels of circulating antiphospholipid antibodies, hemostasis may be impaired resulting in excessive thrombophilia. Both vascular and placental thromboses because of antiphospholipid antibodies or FXIIc deficiency have been reported to be associated with recurrent fetal loss. We have experienced a case of factor XII deficiency in woman with recurrent spontaneous abortion. So we report this case with a brief review of literatures.

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