Clinical and Experimental Reproductive Medicine
- Volume 26 Issue 2
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- Pages.265-269
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- 1999
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- 2233-8233(pISSN)
- /
- 2233-8241(eISSN)
A Case of Antiphospholipid Syndrome Associated with Autoimmune Thrombocytopenic Purpura
자가면역 혈소판감소성 자반병과 관련된 항인지질 증후군 1례
- Nam, Y.S. (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
-
Lee, W.S.
(Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
- Park, C. (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
-
Yoon, T.K.
(Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
- Cha, K.Y. (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University)
- 남윤성 (포천중문의과대학 산부인과학교실) ;
-
이우식
(포천중문의과대학 산부인과학교실) ;
- 박찬 (포천중문의과대학 산부인과학교실) ;
-
윤태기
(포천중문의과대학 산부인과학교실) ;
- 차광열 (포천중문의과대학 산부인과학교실)
- Published : 1999.06.30
Abstract
Thrombocytopenic patients without detectable bound antiplatelet antibody should be diagnosed with idiopathic thrombocytopenic purpura (ITP) if no other cause of their decreased platelet count could be found. More recently the term "autoimmune thrombocytopenic purpura (ATP) has supplanted ITP since the disease is related to the production of autoantibodies against one's own platelets. This entity should not be confused with isoimmune thrombocytopenic purpura (also called alloimmune thrombocytopenic purpura). In this cases maternal antiplatelet antibodies directed against the PLA 1 antigen on the fetal platelets causes severe fetal and neonatal thrombocytopenia in a situation analogous to Rheusus disease. Antibodies to the negatively charged phospholipids, lupus anticoagulant, and anticardiolipin have been linked to adverse pregnancy events. Pregnant women possessing these antibodies have an increased risk of spontaneous abortion, stillbirths, intrauterine fetal growth retardation, preterm birth, and arterial and venous thrombosis. Antiphospholipid antibodies decrease or may even disappear between pregnancies only to recur with increased activity in a subsequent pregnancy and lead to loss. We have experienced a case of antiphospholipid syndrome associated with autoimmune thrombocytopenic purpura in patient with recurrent spontaneous abortion. So we report this case with a brief review of literatures.
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