Korean Journal of Veterinary Pathology (한국수의병리학회지)
- Volume 3 Issue 1
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- Pages.15-25
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- 1999
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- 1226-766X(pISSN)
Cytokine expression and localization during the development of glomerulosclerosis in FGS mice
- Park, Sang-Joon (College of Veterinary Medicine, Kyungpook National University) ;
- Lee, Sae-Bom (Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Lee, Young-Ho (College of Medicine, Chungnam National University) ;
- Ryu, Si-Yun (College of Veterinary Medicine, Chungnam National University) ;
- Jeong, Kyu-Shik (Lab. of Membrane Biochemistry and Biophysics, NIAAA, NIH) ;
- Lee, Cha-Soo (College of Veterinary Medicine, Kyungpook National University)
- Published : 1999.06.01
Abstract
To elucidate the mechanism of age-related development in FGS/NgaKIST mice with spontaneous glomerulosclerotic lesion, we examined expression and localization of various cytokine mRNA in the kidney in the progression of diseases. This mouse model is the first to develop spontanously occuring glomerosclerotic lesion in the kidney. In this study, we detected the up-regulation of local cytokine genes such as IL-1