Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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High Level of Trans-Resveratrol, a Natural Anti-Cancer Agent, Found in Korean Noul Red Wine

  • KIM, KWANG-SEOK (Department of Microbiology, Kyungpook National University) ;
  • SA-YOUL GHIM (Department of Biology Education, Kyungpook National University) ;
  • YOUNG-BAE SEU (Department of Microbiology, Kyungpook National University) ;
  • BANG-HO SONG (Department of Biology Education, Kyungpook National University)
  • Published : 1999.10.01
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Abstract

Resveratrol (trans-3,5,4'-trihydroxystilbene), a phenolic substance present in both grapes and wines, has been reported to have certain pharmacological effects. Using an ethylacetate-phase extraction followed by a high performance liquid chromatographic analysis, the concentration of trans-resveratrol was measured in 9 red wines commercially available in Korea, including the Korean red wine (Noul). Noul red wine with a 1998 vintage had a trans-resveratrol concentration of 3.3 ㎎/l, which was rather higher than the concentrations found in other wines (0.19-2.45 ㎎/l) with the exception of the French wine, J. P. Chenet (3.39 ㎎/l). In addition, the grapes of Vitis labrusca cv. Sheridan cultivated in the Kyungsan area showed a trans-resveratrol content of 6.4 ㎎/㎏.

Keywords

References

  1. Biochem. Biophys. Res. Commun. v.254 Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model Carbo, N.;P. Costelli;F. M. Baccino;F. J. Lopez-Soriano
  2. J. Chromatogr. A v.730 Resveratrol content of some wines obtained from dried Valpolicella grapes: Recioto and Amarone Celotti, E.;R. Ferrarini;R. Zironi;L. S. Conte
  3. Planta Med. v.65 Anti-allergic action of resveratrol and related hydroxystilbenes Cheong, H.;S.-Y. Ryu;K.-M. Kim
  4. Blood v.92 Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells Clement, M.-V.;J. L. Hirpara;S.-H. Chawdhury;S. Perviaz
  5. J. Amer. Soc. Hort. Sci. v.113 Phytoalexin production potential of grape berries Creasy. L. L.;M. Coffee
  6. Transplant. Proc. v.30 Phytoalexin resveratrol (3-4'-4-trihydroxystilbene) modulates granulocyte and monocyte endothelial adhesion Ferrero, M. E.;A. A. E. Bertelli;F. Pellegatta;A. Fulgenzi;M. M. Corsi;A. Bertelli
  7. Planta v.151 Coordinate induction by UV light of stilbene synthase, phenylalanine ammonia-lyase and cinnamate 4-hydroxylase in leaves of Vitaceae Fritzemeier, K.-H.;H. Kindl
  8. Bioorgan. Med. Chem. Letters v.8 Resveratrol as a new type of DNA-cleaving aget Fukuhara, K.;N. Miyata
  9. Proc. Natl. Acad. Sci. USA v.94 Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the eestrogen receptor Gehm, B. D.;J. M. McAndrews;P.-Y. Chien;J. L. Jameson
  10. Am. J. Enol. Vitic. v.46 A global survey of trans-resveratrol concentrations in commercial wines Goldberg, D. M.;J. Yan;E. Ng;E. P. Diamandis;A. Karumanchiri;G. Solese;A. L. Waterhouse
  11. Arch. Pharm. Res. v.32 Antioxidant activity of resveratrol closely correlates with its monoamine oxidase A inhibitory activity Han, Y. N.;S. Y. Ryu;B. H. Han
  12. Am. J. Enol. Vitic. v.46 A global survey of trans-resveratrol concentrations in commercial wines Goldberg,D.M.;J.Yan;E.Ng;E.P.Diamandis;A.Karumanchiri;G.Soleas;A.L.Waterhouse
  13. Carcinogenesis v.20 Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway Huang, C.;W. Ma;A. Goranson;Z. Dong
  14. Science v.275 Cancer chemopreventive activity of resveratrol, a natural product derived grapes Jang, M.;L. Cai;G. O. Udeani;K. V. Slowing;C. F. Thomas;C. W. W. Beecher;H. H. S. Fong;N. R. Farnsworth;A. D. Kinghorn;R. G. Mehta;R. C. Moon;J. M. Pezzuto
  15. Physiol. Plant Pathol. v.9 The production of resveratrol by Vitis vinifera and other menbers of the Vitaceae as response to infection or injury Langcake, P.;R. J. Pryce
  16. Phytochemistry v.33 Antileukaemic compounds derived from stilbenes in Picea abies bark Mannila, E.;A. Talvitie;E. Kolehmainen
  17. J. Agric. Food Chem. v.43 Isolation, characterization, and evolution in red wine vinification of resveratrol monomers Mattivi, F.;F. Reniero;S. Korhammer
  18. Clin. Chim. Acta. v.235 The red wine phenolics transresveratrol and quercetin block human platelet aggregation and eicosanoid synthesis implications for protection against coronary heart disease Pace-Asciak, C. R.;S. Hahn;E. P. Diamandis;G. Soleas;D. M. Goldberg
  19. Arterioscler. Thromb. Vasc. Biol. v.19 Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells: A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine Pendurthi, U. R.;J. T. Williams;L. V. M. Rao
  20. Biochem. Biophys. Res. Commun. v.250 Resveratrol arrests the cell division cycle at S/G2 phase transition Ragione, F. D.;V. Cucciolla;A. Borriello;V. D. Pietra;L. Racioppi;G. Soldati;C. Manna;P. Galletti;V. Zappia
  21. Lancet v.339 Wine, alcohol, platelets, and the French paradox for coronary heart disease Renaud, S.;M. De Lorgeril
  22. Lancet v.338 Prospective study of alcohol consumptin nad risk of coronary disease in men Rimm, E. B.;E. L. Giovannucci;W. C. Colditz;A. Aschrio;B. Rosner;M. J. Stampfer
  23. Plant Physiol. v.97 Biochemical plant responses to ozone: Ⅱ. Induction of stibene biosynthesis in Scots pine (Pinus sylvestris L.) seedlings Rosemann, D.;W. Heller;H. Sandermann, Jr.
  24. Plant Mol. Biol. v.34 An ozone-responsive region of the grapevine resveratrol synthase promoter differs from the basal pathogen-responsive sequence Schulberg, R.;R. Fischer;R. Hain;P. H. Schreier;G. Bahnweg;D. Ernst;H. Sandermann, Jr.
  25. Am. J. Enol. Vitic. v.43 Concentration of the phytoalexin resveratrol in wine Siemann, E. H.;L. L. Creasy
  26. J. Biol. Chem. v.273 Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mannary epithelial cells Subbaramaiah, K.;W.-J. Chung;P. Michaluart;N. Telang;T. Tanabe;H. Inoue;M. Jang;J.-M. Pezzuto;A. J. Dannenberg
  27. J. Biol. Chem. v.273 Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells Subbaramaiah,K.;W.J.Chung;P.Michaluart;N.Telang;T.Tanabe;H.Inoue;M.Jang;J.M.Pezzuto;A.J.Dannenberg