Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Protective Effects of Bifidobacterium spp. on Experimental Colon Carcinogenesis with 1,2-Dimethylhydrazine

  • HAN, MYUNG JOO (Department of Food and Nutrition, Kyung Hee University) ;
  • HAE-YOUNG PARK (Department of Food and Nutrition, Kyung Hee University) ;
  • DONG-HYUN KIM (College of Pharmacy, Kyung Hee University)
  • Published : 1999.06.01
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Abstract

The protective role of Bifidobacterium spp. (B. breve K-110, B. breve K-111, and B. infantis K-525) isolated from the fecal samples of healthy Koreans was investigated on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci(ACF) formation in mouse colon. In mice fed normal diet with DMH treatment, an average of 68.5 ACF/colon was formed, whereas in mice administered with B. breve K-110, B. breve K-111, and B. infantis K-525, the numbers of DMH-induced ACF decreased to 7.2, 10.9, and 6.6 ACF/ colon, respectively. The mean number of crypts/focus was not significantly altered. Fecal harmful enzymes, such as β-glucuronidase, tryptophanase, and urease, were effectively inhibited during the administration of these bifidobacteria to mice. These results suggest that bifidobacteria could prevent colon cancer.

Keywords

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