Journal of Microbiology and Biotechnology
- Volume 9 Issue 1
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- Pages.50-55
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- 1999
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- 1017-7825(pISSN)
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- 1738-8872(eISSN)
Preparation of Nanoparticles in Drug Delivery System Using Guar Derivatives and Dialysis Method
- Na, Kun (Department of Chemical Technology Chonnam National University) ;
- Kim, Yu-Eun (Department of Biomedical Engineering Chonnam National University) ;
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Lee, Ki-Young
(Department of Biochemical Engineering, Institute of Biotechnology, Chonnam National University)
- Published : 1999.02.01
Abstract
To develop a new form of controlled release dosage for administering for indomethacin (IND), two formulations of IND-loaded nanoparticles were designed based on polysaccharide (guar) derivatives. Nanoparticles prepared by the dialysis method were characterized with respect to morphology, size distribution, drug content, and in vitro drug release. Morphological studies by scanning electron microscopy (SEM) indicated that guar acetate (GA) nanoparticles were spherical in shape and had a smooth surface. The particle size distributions of formulation I (40mg of GA) and formulation II (80mg of GA) were shown to be