Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Adhesion Prevention in the Dog with Sodium Carboxymethylcellulose and Low Molecular Weight Heparin

개에서 Sodium Carboxymethylcellulose와 Low Molecular Weight Heparin(Fraxiparine$^{(R)}$)의 유착방지효과

  • Published : 1999.06.01
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Abstract

This study was carried out to compare the efficacy of sodium carboxymethyl cellulose (SCMC) with the combination of low molecular weight heparin (LMWH) and SCMC for the prevention of postoperative adhesions in the dog. After laparotomy, abrasions were made on the surface of ileal serosa in 17 dogs. The animals were randomly divided into the control group (N = 5) which received no treatment, the SCMC-treated group (N = 6), and the SCMC ＆ LMWH-treated group (N = 6). Hematologic values were monitored before laparotomy and 1, 4, 7, 10 and 14 days after laparotomy. The location and score of adhesion were assessed at second laparotomy 3 weeks later, Although the mean adhesion score both in the SCMC-treated group (7.17${\pm}$1.17) and in the SCMC & LMWH-treated group (4.50${\pm}$1.38) was found to be significantly lower than that in the control group (9.40${\pm}$0.89) (p<0.01 and p＜0.01, respectively), more favorable adhesion prevention was achieved in the SCMC ＆ LMWH-treated group in comparison with the SCMC-treated group without any hemor-rhagic complications (p<0.01). This study could conclude that SCMC ＆ LMWH are highly effective in prevention against postoperative adhesion in the dog.

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References

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