Changes of the Somatostatin-immunoreactive Cells in the Pancreas of the Korean Native Goat (Capra hircus) during Development

  • Sae-Kwang Ku (Pharmacology and Toxicology Laboratory, Central Research Laboratories, Dong-Wha Pharmacetucal Industry Co.) ;
  • Ki-dae Park (Laboratory of Histology, College of Veterinary Medicine, Kyungpook National University) ;
  • Hyeung-Sik Lee (Department of Biology, Faculty of Basic Sciences, Kyungsan University) ;
  • Jae-Hyun Lee (Laboratory of Histology, College of Veterinary Medicine, Kyungpook National University)
  • Published : 1999.09.01

Abstract

The distribution and relative frequency of somatostatin-immunoreactive cells in the pancreas were studied during developmental stages (fetus, neonate, 1-month-old, 6-month-old and adult) of the Korean native goat by immunohistochemical methods. Somatostatin-immunoreactive cells were detected in the exocrine of all ages, in the endocrine portions (pancreatic islets) from the neonate, and in the pancreatic duct of the 1-month-old. The relative frequencies of these cells in the pancreatic islets increased with age. However, there were no age-related changes in the relative frequencies of somatostatin-immunoreactive cells in the exocrine and pancreatic duct. Generally, they were distributed in the interacinar spaces, the epithelium of the pancreatic duct, or dispersed in the peripheral zone of the pancreatic islets in all ages. However, clusters consisting of 3-4 cells were also found in the subepithelial connective tissues from the 1-month-old. In addition, the distributions in the endocrine portions of the adult were divided into two patterns: 1) they are dispersed in the marginal regions with moderate or low frequencies, or 2) in the inner zone with high frequencies.

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