Sprague-Dawley계 정상흰쥐에서 포도당 내성과 인슐린 감수성에 대한 Cyclosporine의 영향

Effects of Cyclosporine on Glucose Tolerance and Insulin Sensitivity in Sprague-Dawley Rats

  • 강주섭 (한양대학교 의과대학 약리학교실의과학연구소) ;
  • 고현철 (한양대학교 의과대학 약리학교실의과학연구소) ;
  • 이창호 (한양대학교 의과대학 약리학교실의과학연구소) ;
  • 신인철 (한양대학교 의과대학 약리학교실의과학연구소) ;
  • 김동선 (한양대학교 의과대학 약리학교실의과학연구소) ;
  • 양석철 (한양대학교 의과대학 내과학교실) ;
  • 전용철 (한양대학교 의과대학 내과학교실)
  • 발행 : 1999.12.01

초록

This study was performed to investigate the effect of cyclosporine (CsA) on glucose tolerance and peripheral insulin sensitivity in normal Sprague-Dawley rats. After daily treament of CsA (10 mg/kg, i.p.) for two weeks, glucose tolerance tests were carried out by the treatment of glucose (Glu, 2 g/kg, i.p.) alone or in conjunction with exogenous insulin (Ins; human regular insulin, 5 U/kg, s.c.) and measured the decrement of area under the time-plasma glucose concentration curve ($AUC_{o\longrightarrow120}$; g.min/ml) by the trapezoidal rule. The rats were divided into three groups (Glu- (Control), Ins+Glu- and CsA+Ins+Glu-, n=7 in each group). The $AUC_{o\longrightarrow120}$ of the CsA+Ins+Glu-group was significantly (p<0.01) lower than that of Glu-group (61.0% of control) and significantly (p<0.05) higher than that of Ins+Glu-group (197.4% of Ins+Glu-). The CsA+Ins+Glu- grou showed higher levels of maximal blood glucose concentration and higher $AUC_{o\longrightarrow120}$ than those of Ins+Glu-group in normal rats. Besides direct pancreatic toxicity of CsA previously reported (Hahn et al., 1972), these results suggest that CsA also make the possibility to induce peripheral insulin insensitivity and glucose intolerance in normal rats.

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