Pharmacokinetic and Pharmacological Evaluation of Topical Microemulsion Preparation Containing Piroxicam

마이크로에멀젼으로 제제 설계된 피록시캄 외용제의 약물동력학적 특성 및 약효 평가

The pharmacological activities and pharmacokinetic aspects of a topical microemulsion (KDPM) containing 0.5% piroxicam were evaluated after its topical application compared with a commercially available 0.5% piroxicam gel (R gel). When the pharmacological activities were evaluated with the carrageenan-induced paw edema model, KDPM showed 55.6% edema inhibition, while R gel resulted in 37.1%. With the adjuvant-induced arthritis model, KDFM also resulted in the better pharmacological activities than R gel. The relative bioavailability of KDPM based on R gel was 176% in rabbits.