Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Iron Status in Pregnant Women and Their Newborn Infants

임신부와 신생아의 철분 영양상태에 관한 연구

  • 김은경 (강릉대학교 생명과학대학 식품과학과)
  • Published : 1999.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purposes of this study are to assess iron status in mothers and their newborn infants at birth and to analyze the influence of maternal iron status on their newborn babies. Venous bloods samples were drawn from 144 pregnant women just before delivery and cord bloods of their newborn babies were collected immediately after birth for measurement of hemoglobin, hematocrit, serum iron, ferritin, total binding capacity and transferrin saturation. The values of hemoglobin and hematocrit were significantly lower in the mothers(10.9$\pm$1.43g/dl and 33.7$\pm$3.67%) than in their newborn infants(14.7$\pm$1.43g/dl and 45.3$\pm$4.76%)(p<0.0001). At delivery, serum iron levels in cord blood were about twice as high as those in the maternal blood, and serum ferritin levels in the cord blood were about four times higher than those in the maternal blood. The serum ferritin levels of multigravidas were higher than those of primigravidas,. but there was no difference between the serum ferritin levels of their infants. The serum ferritin levels of the mothers and their infants were higher in maternal group with iron supplement regularly than in other maternal group without iron supplement during pregnancy. Among the mothers, 26.4% had a serum ferritin levels below 12ng/ml(i.e. depleted iron stores)and 78.9% had a hemoglobin below 12g/dl(i.e.iron deficient anemia). When the maternal group was classified according to their serum ferritin levels by 9ng/ml, 12ng/dl or 20ng/ml, there was no significant difference in the iron status of their newborn infants among the three groups. The hemoglobin and serum ferritin levels of the mothers were well correlated with those of their babies. The maternal hemoglobin values negatively correlated with infant birth weight. It is possible that the demands of iron of the mother might be increased in the case of a newborn infant of greater size. The results of this study provide useful information regarding establishment of RDA for iron in pregnant women and guidance about the need for iron supplement during pregnancy.

Keywords

References

  1. Int J Gyne Obst v.8 Clinical and laboratory significance of variations in maternal plasma volume in pregnancy Liley AW
  2. Am J Obst Gyne v.124 Patients of high risk for low birth weight delivery Kaltreider DF;Johnson JW
  3. INSERM v.113 Effects of maternal anemia on the newborn infant and the placenta Singla PN;Agarwall KN
  4. Br Med J v.4 Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload Jacobs A;Miller F;Worwod M;Beamish MR;Waldrop CA
  5. Dan Med Bull v.30 Serum ferritin in healthy Dares:relation to bone marrow haemosiderin iron stores Milman N;Pedersen NS;Visfeldt J
  6. Acta Obst Gyne Scan v.95(Suppl.) Serum ferritin as a measure of iron stores during and after normal pregnancy with and without iron supplement Puolakka J;Janne O;Pakarinen A;Jarvinen PA;Vihko R
  7. J Obst Gyne v.159 Comparison of tests for diagnosis of iron depletion in pregnancy Thompson WG
  8. Am J Obst Gyne v.152 The role of transferrin and ferritin in the fetal-maternal placental unit Okyuama T;Tawada T;Furaya H;Villee CA
  9. Ann Nutr Met v.27 Iron supplements versus placebo during pregnancy: Its effects on iron folate status on mothers and newborns Zittoun J;Blot I;Zittoun R;Papiernik E;Tchernia G
  10. Obst Gyne v.57 Serum ferritin as an assessment of iron stores and other hematologic parameters during pregnancy Kaneshige E
  11. Acta Obst Gyne Scan v.66 Serum ferritin and iron status in mothers and newborn infants Milman N;Ibsen KK;Christensen JM
  12. Am J Dis Child v.124 Iron status of a medical high-risk population at delivery Shott RJ;Andrews BF;Ky L
  13. Acta Obst Gyne Scand v.72 Relationship between iron status in pregnant women and their newborn babies Gaspar MJ;Ortega RM;Moreiras O
  14. Korean J Nutrition v.24 no.5 Hemoglobin, hematocrit and serum ferritin as markers of iron status Chung HR;Moon HK;Song BH;Kim MK
  15. Korean J community Nutrition v.2 no.1 Iron nutritional status of female students in Kangnung national university Lee KH;Kim EK;Kim MK
  16. Korean J Nutrition v.25 no.5 A survey on iron intake and nutritional status of female college students of Chungnam national university Nam HS;Ly SY
  17. Korean J Nutrition v.26 no.6 Iron nutrition and related dietary factors in apparently healthy young Korean women(1): Comparison and evaluation of blood biochemical indices for assessment of iron nutrition status Kye SH;Paik HY
  18. J College Medicine Korea University v.16 no.3 Iron concentration in maternal blood and neonatal cord blood of some Seoulities Kim SJ
  19. Korean J Pediatrics v.24 no.7 A study on the differences in blood pictures of premature babies and term babies Kim KC
  20. Korean J Pediatrics v.25 no.9 Study on cord blood hemoglobin and etiology of neonatal anemia Lee C;Cho HJ;Lee MH;Park SJ;Lee YH
  21. Korean J Pediatrics v.35 no.12 The relationship between neonatal hypoglycemia and newborn iron status in hypoglycemic large-for-gestational age infants Yoon MJ;Song IH;Jung HL;Kum DH
  22. Korean J community Nutrition v.3 no.4 Effects of maternal anemia on the iron status of the cord blood and pregnancy outcomes Lim HS;Kim HA
  23. Korean J Lipidology v.6 no.1 Dietary fat intakes of pregnant women and fetomaternal serum lipids and fatty acid composition Ahn HS;Park SH
  24. JAMA v.116 The effect of depriving the infant of its placental blood, on the blood picture during the first week of life De Marsh QB;Windle WF;Hillis DS
  25. Acta Obst Gyne Scand v.72 Relationship between iron status in pregnant women and their newborn babies Maria JG;Rosa O
  26. J Obst Gyn v.66 The normal cord hemoglobin level Burman D
  27. Int J Vit Nutr Res v.57 Iron status in Ecudorian pregnant women living at 2800m altitude: Relationship with infant iron status Yepez R;Calle A;Galan P(et al.)
  28. Korean J Nutrition v.26 no.1 Serum folate and iron levels of pregnant, lactating, and non-pregnant, non-lactating women Chang NS;Kang MH;Paik HY;Kim IH;Cho YW;Park SC;Shin YW
  29. Korean J Nutrition v.23 Huh KB
  30. Am J Clin Nutr v.54 Serum transferrin receptor for the detection of iron deficiency in pregnancy Merisa TC;Barry SS;Brent F;Bonnie C;James DC
  31. J Repro Med v.62(suppl.) Protection of iron stores in pregnancy Dawson EB;Mc Ganity WT
  32. Obst Gyne v.90 The requirement in normal pregnancy as assessment of serum ferritin, serum transferrin saturation, erythrocyte propoporphyrin determination Romslo I;Haram K;Sagen N;Augense C
  33. Am J Dis Child v.124 no.sept Iron status of a medical high risk population at delivery Roger JS;Billy F;Andrews Lky
  34. J Obst Gyne Br Comm v.75 Neonatal and maternal serum iron levels at birth Kessel I;Sills DJ
  35. Relationship between the hemogram of the infant and that of the mother during pregnancy Calvin WW;Edwin BB
  36. Clin Obst Gyne v.37 no.3 Nutritional supplementation for the pregnant woman Lindsay HA
  37. Nutrition During Pregnancy Institute of Medicine
  38. J Clin Pathol v.26 Serum ferritin concentration and iron stores in normal subjects Waters GO;Miller FM;Worwood M
  39. Clin Exp Obst Gyne v.30 Iron balance in pregnancy in relation to anemia Carretti NG;Eremita AG;Paternoster D;Pellizzari P;Grella P
  40. Acta Obst Gynec Scan v.70 Iron supplementation during pregnancy Guldholt IS;Trolle BG;Hviman LE
  41. Acta Obst Gyne Scand v.72 Low dose iron supplement dose not cover the need for iron during pregnancy Thomsen JK;Prien-Larsen JC;Devantier A;Forgh-Andersen N
  42. Canadian J Public Health v.83 Iron status and pregnancy in a Northern Canadian population:Relationship to diet and iron supplementation Godel JC;Pabst HF;Hodges PE;Johnson KE
  43. Korean J Nutrition v.31 no.8 The effects of weekly iron supplementation on iron and zinc nutritional status in pregnant women Yu KH;Yoon JS
  44. British J Heamatology v.37 Iron stores in pregnancy Fenton V;Cavill I;Fisher J