Journal of Nutrition and Health

  • 제32권4호
  • /
  • Pages.369-375
  • /
  • 1999
  • /
  • 2288-3886(pISSN)
  • /
  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

갑상선 호르몬이 흰쥐 간세포내 엽산의 Polyglutamate 직쇄분포와 세포질 엽산 결합단백질의 결합성에 미치는 영향

Effects of Thyroid Hormone on Pteroylpolyglutamate Chain Length and the Binding Activity of Folate Binding Protein in Rat Liver

  • 민혜선 (한남대학교 식품영양학과)
  • 발행 : 1999.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Hyperthroidism in known to alter the activity of a number of enzymes involved in the catabolism of histidine to CO2. 10-Formyltetrahydrofolate dehydrogenase(EC 1.5, 1.6, 10-formyl-THE dehydrogenase) catalyzes the NADP-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. In previous studies, 10-formyl-THF dehydrogenase purified from rat and pig liver was coidentified with the cytosolic folate-binding protein. In this study, we investigated the effects of feeding thyroid powder (TP) and thiouracil(TU) on the folate-binding properties of 10-formyl-THE dehydrogenase, the uptake of an injected dose of [3H] folate, and the metabolism of labeled folate to pteroylopoly-${\gamma}$-glutamate in rat liver. The initial hepatic uptake(24hr) of the labeled folate dose was higher in TU-rats and slightly higher in TP-rats in controls. With longer time periods, decreased hepatic uptake of labeled folate was observed in TP-animals compared to euthroid animals, and high levels of hepatic uptake of labeled folate were maintained in TU-animals. This data shows that high levels of thyroid hormone decreased the retention of folate in rat liver. Folate polygutamate chain length was shorter in TU-rats than controls, which suggests that thyroid states do not affect the ability to synthesize pteroylpolyglutamates and that folate polyglutamate might be modulated by altered folate pool size. The ability of 10-formyl-THE dehydrogenase to bind folate in rat liver was similar in both TP-and TU-rats although dehydrogenase activity was changed by thyroid sates.

키워드

참고문헌

  1. Biochim Biophys Acta v.632 Metabolic responses of folic acid and related compounds to thyroxine in rats Chan MM-S;Stokstad ELR
  2. Kor J Nutr v.24 no.4 The effect of thyroxine status on hepatic levels of 10-formyltetrahydrofolate dehydrogenase Min H
  3. Ann N Acad Sci v.355 Nutritional interaction of vitamin B12, folic acid, and thyroxine Stokstad ELR;Chan MM-S;Watson JE;Brody T
  4. Proc Soc Exp Biol Med v.161 Effect of dietary thyroid powder on urinary excretion of formiminoglutamic acid and methylmalonic acid Barta KK;Watson JE;Stokstad ELR
  5. Biochemical and Clinical Aspects of Pteridines v.2 Role of thyroxine in regulation of folic acid metabolism Stokstad ELR;Chan MM-S;Watson JE;Urban G
  6. Arch Biochem Biophys v.328 Quantification of the carbon flow through the folate-dependent one-carbon pool using radiolabeled histidine : Effect of altered thyroid and folate status Schalinske KL;Steele RD
  7. Methods Enzymol v.18B 10-Formyltetrahydrofolate : NADP oxidoreductase Kutzbach C;Stokstad ELR
  8. Biochim Biophys Acta v.871 Formyltetrahydrofolate dehydrogenase-hydrolase from pig liver : simultaneous assay of the activities Rios-Orlani EM;Zarkadas CG;MacKenzie RE
  9. Biochem J v.177 Inhibitory effects of Histidine and their reversal. The role of pyruvate carboxylase and $N^{10}$-formyltetrahydrofolate dehydrogenase Scrutton MC;Beis I
  10. Biochem J v.158 The regulation of folate and methionine metabolism Krebs HE;Hems R;Tyler B
  11. Biochemistry v.35 Properties of tetrahydropteroylpentaglutamate bound to 10-formyltetrahydrofolate dehydrogenase Kim DW;Huang T;Schirch D;Schirch V
  12. Mol Pharmacol v.31 Studies on the role of folic acid and folate-dependent enzymes in human methanol poisoning Johlin FC;Fortman CS;Nghiem DD;Tephly TR
  13. Mol Pharmacol v.35 Studies on the mechanism of methanol poisoning : purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase Johlin FC;Swain E;Smith C;Tephly TR
  14. Biochim Biophys Acta v.967 Identification of 10-formyltetrahydrofolate dehydrogenase-hydrolase as a major folate binding protein in liver cytosol Min H;Shane B;Stokstad ELR
  15. J Biol Chem v.255 Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products McGuire JJ;Hsieh H;Coward JK;Bertino JR
  16. Arch Biochim Biophys v.181 Folate-dependent enzymes in cultured chinese hamster cells : Folylpolyglutamate synthetase and its absence in mutants auxotrophic for glycine+adenosine+thymidine Taylor RT;Hanna ML
  17. Mol Cell Biochem v.39 Folylpolyglutamate synthesis by bacteria and mammalian cells Cichowicz DJ;Foo SK;Shane B
  18. J Biol Chem v.252 Identificaiton of folate binding protein binding proteins of rat liver Zamierowski M;Wagner C
  19. Am J Clin Nutr v.35 High performance liquid chromatography of folates Shane B
  20. Biochim Biophys Acta v.497 Uptake and metabolism of [³H]folate by normal and by vitamin B-12 and methionine-deficient rats Shane B;Watson JE;Stokstad ELR
  21. J Nutr v.122 Incorporation of 3H-label from folic acid is tissue-dependent in folate-deficient rats Eisenga B;Collins TD;McMartin
  22. J Nutr v.122 Long-term folate deficiency alters folate content and distirbution differentially in rat tissues Varela-Moreiras;Selhub J
  23. Biochim Biophys Acta v.585 Folates of rat tissue. Bioassay of tissue folylpolyglutamates and relationship of liver folylpolyglutamates to nutritional folate sufficiency Richardson RE;Healy MJ;Nixon PF
  24. Biochim Biophys Acta v.633 An inverse relationship of rat liver folate polyglutamate chain length to nutritional folate deficiency Cassady IA;Budge MM;Healy MJ;Nixom PF
  25. J Nutr v.120 Modulation of pteroylpolyglutamate concentration and length in response to altered folate nutrition in comprehensive range of rat tissues Ward GJ;Nixon PF
  26. Ann Res Nutr v.2 Cellular folate binding proteins : Function and significance Wagner C
  27. Biochem Biophys Res Commun v.127 Inhibition of glycine N-methytransferase by folate derivatives : Implication for regulation of methyl group metabolism Cook RJ;Wagner C
  28. Proc Natl Acad Sci USA v.91 Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice Champion KM;Cook RJ;Tollaksen SL;Giometti CS
  29. J Toxicol Environ Health v.1 Metabolism of formate in the rat Palese M;Tephly TR
  30. Proc Natl Acad Sci v.82 Role of hepatic tetrahydrofolate in the species difference in methanol toxicity Black KA;Eells JT;Noker PE;Hawtrey CA;Tephly TR