Evaluation of Zinc and Copper Status in Korean College Women

일부 여대생의 구리와 아연 영양상태 평가

  • 김정혜 (서울대학교 생활과학대학 식품영양학과)
  • Published : 1999.04.01

Abstract

This study was conducted to assess dietary intake and nutritional status of zinc and copper in Korean college women. Dietary survey was conducted by 24-hour recall method and fasting serum samples were collected from 111 apparently healthy subjects. Intake levels of zinc and copper were calculated using newly developed database for Zn & Cu of Korea food. Serum levels of Zn, Cu and activities of ALP, EC-SOD were measured from fasting serum sample. Mean daily zinc and copper intakes were 6.72mg/day(56.0% RDA) and 1.11mg/day respectively. Mean values of serum ALP activity, zinc and copper concentration were 43.9U/L, 14.8umol/1, 15.5umol/1and these values were mostly within normal range. EC-SOD activitis of the subjects were low and had no correlation with intake or serum levels of Zn, Cu. In conclusion, these results show that zinc and copper intake of Koran college women are lower than those from other counties but higher than those of adults in rural area of Korea. Their serum levels of Zn, Cu, ALP are relatively normal. These results indicate that marginal deficiency of Zn and Cu may be quite prevalent in these subjects but serum indicators measured may not be sensitive enough to detect such marginal deficiency. Further study in needed to develop a biochemical index sensitive enough to evaluate Zn and Cu status.

Keywords

References

  1. Clin Chem v.40 no.8 Assessment of copper nutritional status Miline DB
  2. Am J Clin Nutr v.32 On the assessment of zinc and copper nutriture in man Solomons NW
  3. Biol Trace Elem Res v.61 no.3 Blood levels of copper, zinc, and lead in adu-1ts in India and Pakistan and the effect of oral zinc supplementation for six weeks Abdulla M;Suck C
  4. Am J Clin Nutr v.63 Limits of metabolic tolerance to copper and biological basis for present recommendation and regulations Olivare M;Uauy R
  5. Clin Chem v.21 no.4 Newer aspects of the roles of zinc, manganese, and copper in human nutriture Burch RE;Hahn HKJ;Sullivan JF
  6. Principles of Nutritional Assessment Gibson RS
  7. Am J Clin Nutr v.39 Tissue zinc levels and zinc excretion during experimental zinc depletion in young men Baer MT;King JC
  8. J Nutr v.124 Daily variation in plasma zinc concentrations in women fed meals at six hour intervals King JC;Hambidge KM;Westcott JM;Kern DL;Marshall G
  9. J Trace Elem v.4 no.4 Prebreakfast plasma zinc concentration : The effect of previous meals Hambidge KM;King JC;Kern DL;English-Westcott JL;Stall C
  10. Am J Clin Nutr v.61 Extracellular superoxide dismutase activity is affected by dietary zinc intake in nonhuman primate and rodent models Olin KL;Golub MS;Gershwin ME;Hendrickx AG;Lonnerdal B;Keen CL
  11. Am J Clin Nutr v.59 Copper deficiency affects selenoglutathione peroxidase and selenodeiodinase activities and antioxidant defence in weaning rats Oliln KL;Golub MS;Keen CL
  12. Clinica Chimni Acta v.229 Quantitative and qualitative changes of extracellular superoxide dismutase in patients with disease Adachi T;Nakamura M;Yamada H;Futenma A;Kato K;Hirano K
  13. J Biol Chem v.267 Regulation by cytokines of extracellular superoxide dismutase and other superoxide dismutase isozymes in fibroblasts Marklund SL
  14. Biol Trace Elem Res Serum extracellular superoxide activity as an indicator of zinc status in human Paik HY;Joung HJ;Lee JY;Lee HK;King JC;Keen CL
  15. Am J Clin Nutr v.42 Evaluation of zinc and copper nutritional status and effects upon growth of southern adolescent females Sloane BA;Gibbons C;Hegsted M
  16. Recommended Dietary Allowances For Koreans(6th revision) The Korean Nutrition Society
  17. Korean J Nutrition v.31 no.8 Supplementation of zinc nutrient database and evaluation of zinc intake of Korean adults living in rural area Lee JY;Joung HJ;Paik HY
  18. Preparation of copper database of Korean foods and evaluation of zinc and copper status of college women Kim CH
  19. Research Institute of Human Ecology v.DS24
  20. J Nutr v.113 Changes in tissue growth, concentration of copper, iron, cytochrome oxidase and superoxide dismutase subsequent to dietary or genetic copper deficiency in mice Prohaska JR
  21. J Am Diet Assoc v.90 Zinc : Consumption patterns and dietary recommendations Phylis B;Moser-Veiion
  22. J Nutr v.126 Deliberations and evaluations of approaches, endpoints and paradigms for determining zinc dietary recommendations Harold HS;J Ceil Sith
  23. Trace elements in human nutrition and health WHO
  24. Sci Total Environ v.205 Serum concentration and dietary intake in healthy institutionalized elderly subjects R Artacho;Ruiz-Lopez;C Gamez;A Peutra;MC Lopez
  25. J Nutr v.124 Estimates of trace element in Chinese Farmers Fan C;Philip C;Lifang W;Zhibao M;Edward JT
  26. Am J Clin Nutr v.56 Effects of age and sex on copper absorption, biological half-life and status in humans Johnson PE;Miline DB;Lykken GE
  27. J Hyg Epidemiol Microbiol Immunol v.32 no.3 Dietary copper intake of the population Hejda S;Osancova K;Cervenkova D
  28. J Am Dietetic Assoc v.88 Copper nutriture, bioavailability and the influence of dietary factors Turnlund JR
  29. Korean J Nutrition v.26 no.9 Dietary Copper intakes and effect of zinc supplementation on plasma copper level in Korean adults C hyun GH;Choi YJ
  30. Korean J Nutrition v.29 no.10 The relationship between dietary intakes, serum levels, urinary excretions of Zn, Cu, Fe and serum lipids in Korean adults on self selected diet Lee JY;Choi MK;Sung CJ
  31. Biol Trace Elem Res v.51 no.3 Is erythrocyte alkaline Phosphatase activity a marker of zinc status in human? Samman S;Soto C;Cooke L;Ahmad Z;Farmakalidis E
  32. Am J Clin Nutr v.47 Zinc status of healthy elderly adults : response to supplementation zinc-deficient male rats Christine As;Robert MBS;Charles HR
  33. Am J Clin Nutr v.33 Serum alkaline phosphatase after treatment of zinc deficiency in humans Kasarskis EJ;Schuna A
  34. Federation of Americal Society for Experimental Biology Assessment of the zinc nutritional status of the U. S. population based on data collected in the second National Health and Nutritional Examination Survey Pilch SM;Senti FR
  35. Sci Total Environ v.39 no.1-2 The interpretation of human hair trace element concentrations Gibson RS;Gibson IL
  36. A comprehensive guide for planning intervention 2th AN ASPEC PUBLICATION Nutrition assessment Simko MD;Correl C;Gilbride JA
  37. Scand J Clin Lab Invest v.42 no.1 Copper and zinc in human serum in Norway : Relationship to geography, sex and age Helgeland K;Haider T;Jonsen J
  38. J Trace Elem Med Biol v.11 no.2 Reference values for the trace elements copper, manganese, selenium and zinc in the serum/plasma of children, adolescent and adults Rukgauer M;Klein J;Kruse-Jarres JD
  39. J Med Assoc Thai v.79 no.9 Serum zinc and copper in healthy adults living in Bangkok and surrounding districts Songchitsomboon S;Komindr S
  40. Physiol Res v.43 no.2 Serum copper, zinc and copper/zinc ratio in males : Influence of aging Madaric A;Ginter E;Kadrabova J
  41. Tohoku J Exp Med v.120 no.2 Serum zinc, copper levers in healthy Japanese children Ohtake M;Tamura T
  42. Am J Clin Nutr v.35 Copper levels in plasma and erythrocytes in healthy Japanese children and adults Hatabo S;Nishi Y;Usui T
  43. Biol Trace Elem Res v.18 Serum copper, zinc levels, and copper zinc ratio in healthy women and women with gynecologic tumors Centinkaya N;Centinkaya D;Yuce M
  44. J Surg Oncol v.52 no.3 Serum and tissue trace elements in colorectal cancer Gupta SK;Shukla VK;Vaida MP;Roy SK;Gupta S
  45. Clin Biochem v.18 no.6 Copper, zinc and copper/zinc ratio in chronic pancretitis and pancreatic cancer Fabris C;Farini R;Del Favero G;Gurrieri G;Piccoli A;Naccarato R
  46. Arch Med Res v.28 no.2 Diagnostic value of the copper/zinc ratio in digestive cancer : A case control study Poo JL;Romero RR;Robels JA;Montemayor AC;Isoard F;Estanes A;Uribe M
  47. Jpn J Surg v.18 no.2 Serum zinc and copper changes after gastrectomy in aged patients with gastric cancer Hisaki T;Furumoto T;Nozaka K;Koga S
  48. Gan No Rinsho v.32 no.12 Serum copper and the copper : Zinc ratio in patients with gastric cancer Mimata Y;Ujiie S;Himori T;Wakui A