Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Serum Fatty Acids in Patients with Angiographically-Documented Coronary Artery Disease

관상동맥질환자의 혈청 지방산 조성에 관한 연구

  • 김수연 (연세대학교 식품영양학과)
  • Published : 1999.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

To study the relation between serum fatty acids and coronary artery disease(CAD), 194 subjects were randomly selected and divided into three groups(control, single vessel disease group(SVD), muliple vessel disease group(MVD)) according to the angiographic results. Total serum levels of fatty acids and serum phospholipid(PL)-fatty acids(FAs)were analysed using gas chromatography and their associations with CAD were examined. Different patterns of total serum fatty acid levels were found in men and women. Levels of most fatty acids of SVD and MVD were significantly lower in men, while those of MVD were significantly higher in women. In terms of PL-FAs in both men and women, the levels of PL-FAs follow the order of control < SVD < MVD and in women, the difference was significant. Various ratio(including ratios denoting the activites of desaturase and elongase) of total serum-and PL-FAs were similar in the three groups. In the relation of serum fatty acids to serum lipid profiles, PUFA & LDL showed a negative correlation, while, SFA & LDL-cholesterol and PUFA and HDL-cholesterol showed positive correlatons. correlations. Systolic blood pressure and alcohol intake levels negatively affected the levels of serum LA, AA, EPA and DHA in the risk factor analysis. These findings are consistent with other evidence indicating that fatty acid compositions are changed in CAD, especially on the concentration base and the change was related to the severity of the disease. Therefore, for the purpose of disease prevention and therapeutic use, balanced intakes of various fatty acids must be seriously considered.

Keywords

References

  1. Nutritional Epidemiology Willett W
  2. J Clin Nutr v.6 no.2 Nutrition and cardiovascular disease : An Asia Pacific perspective Khor GL
  3. Am J Epidemiol v.119 Ten-year incidence of coronary heart disease in the Honolulu heart program : relationship to nutrient intake MaGee DL;Reed DM;Yano K;Kagan A;Tillotson J
  4. New Engl J Med v.321 Diet and 20-year mortality from coronary heart disease : The Ireland-Boston Diet-Heart Study Kushi LH;Lew RA;Stare FJ;Ellison CR;Bourke G;Daly L;Graham I;Hickey N;Mulcany R
  5. J Chronic Disease v.26 Goldbourt U Five-year myocardial infarction incidence-II : Association of single variables to age and birth place Medalie JH;Kahn HA;Neufeld HN;Riss E
  6. New Engl J Med v.304 Diet, serum cholesterol, and death from coronary heart disease : The Western Electric Study Shekelle RB;Shryock AM;Paul O;Lepper M;Stamler J;Liu S;Raynor WJ
  7. Lipids v.31 A new relationship between total/high density lipoprotein cholesterol and polyunsaturated fatty acids Siguel E
  8. Am J Epidemiol v.142 Serum fatty acids and the risk of coronary heart disease Simon JA;Hodgkins ML;Browner WS;Neuhaus JM;Bernert JT;Hulley SB
  9. Lancet v.2 Fatty acids and myocardial infarction follow-up of patients with aortoiliac and femoropopliteal atherosclerosis Kingsbury KJ;Morgan DM;Stovold R;Brett CG;Anderson J
  10. Prog Lipid Res v.23 Effect of unsaturated acids on membrane structure and enzyme kinetics Brenner RR
  11. Metabolism v.43 no.8 Altered fatty acid metabolism in patients with angiographically documented coronary artery disease Siguel EN;Lerman R
  12. Clin Chem v.39 no.4 Comparison of lipid fatty acids on a concentration basis vs weight percentage basis in patients with and without coronary artery disease or diabetes Schwertner HA;Mosser EL
  13. Korean J Nutrition v.30 no.8 Nutrients and individual fatty acids intake patterns in the coronary artery disease patients with different degrees of stenosis Kim SY;Lee-Kim YC;Cho SY
  14. J Biol Chem v.226 A simple method for isolation and purification of total lipids from animal tissues Folch J;Lees M;Stanley S
  15. J Lipid Res v.27 Direct transesterification of all classes of lipids in a one-step reaction Lepage G;Roy CC
  16. Br Heart J v.73 Antioxidant nutritions, atherosclerosis and coronary heart disease Oliver MF
  17. Korean J Lipidology v.5 no.2 Fatty acid intake patterns and compositions serum phospholipids-fatty acids of the Korean adults Oh KW;Lee SI;Song KS;Nam CM;Kim YO;Lee-Kim YC
  18. Nutr Support Serv v.8 Nutrient charts : Essential fatty acid Siguel EN
  19. N Engl J Med v.328 The relationships between insulin sensitivity and the fatty acid composition of skeletal muscle phospholipids Bordman M;Storlien LH;Pan DA;Jenkins AB;Chisholin DJ;Campbell LB
  20. Atherosclerosis v.99 Fatty acid composition in total phospholipids of human coronary arteries in sudden cardiac death Luostarinen R;Boberg M;Saldeen T
  21. Atherosclerosis v.124(suppl) Triglyceride : A risk factor for coronary heart disease Darignon J;Cohn JS
  22. Clinical Nutrition and Dietetics(2nd ed.) Zeman FF
  23. Nutrition Today v.31 no.3 Effects of individual fatty acids on chronic diseases Jonnalagadda SS;Mustad VA;Yu S;Etherton TD;Kris-Etherton PM
  24. Harper's Biochemistry(24th ed.) Murray RK;Granner DK;Mayes PA;Rodwell VW
  25. Ann Epidemiol v.6 The role of socioeconomic status and serum fatty acids in the relationship between intake of animal foods and cardiovascular risk factors Yeh LLL;Kuller LH;Bunker CH;Ukoli FA;Huston SL;Terrell DF
  26. Hypertension v.8(SII) Preliminary observations on abnormalities of membrane structure and function in essential hypertension Naftilan AJ;Dzau VJ;Loscalzo J
  27. Intern J Epidemiol v.16 Adipose tissue fatty acids and blood pressure in middle-aged men from southern Italy Rubba P;Mancini M;Fidanza F;Gautiero G;Salo M;Nikkari T;Elton R;Oliver MF
  28. Hypertension v.12 Release of fatty acids by perfused vascular tissue in normotensive and hypertensive rats Mtabaji JP;Manku MS;Horrobin DF