Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Houttyunia cordata Ethanol Extracts on Serum Lipids and Antioxidant Enzymes in Rats Fed High Fat Diet

고지방 식이에 따른 어성초 추출물 투여가 혈청지질 및 항산화 효소 활성에 미치는 영향

  • 정차권 (한림대학교 식품영양학과) ;
  • 함승시 (강원대학교 식품생명과학부) ;
  • 이상영 (강원대학교 식품생명과학부) ;
  • 오덕환 (강원대학교 식품생명과학부) ;
  • 최수용 (한국원자력병원 임상의학실) ;
  • 강일준 (한림대학교 식품영양학과) ;
  • 남상명 (한림대학교 식품영양학과)
  • Published : 1999.02.01
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Abstract

Effects of Houttuynia cordata ethanol extracts on lipid metabolism and antioxidant enzymes in Sprague Dawley male rats were investigated. High fat used in the diet mixture included 10% of lard, 1% of cholesterol and 0.25% of sodium cholate. Total serum cholesterol contents of the rats fed Houttuynia cordata extracts were decreased compared to the control. On the other hand, HDL cholesterol contents were increased along with the decrease of athrogenic index. When high fat diet was fed, total serum cholesterol contents were significantly increased(p<0.01) with the athrogenic index increase of four times of the control. With the administration of Houttuynia cordata extract HDL cholesterol was increased by 53% in the high fat diet group. Antioxidant enzymes including GST and catalase activities were increased comparing the control. On the otherhand, the extracts lowered phospholipid(p<0.01), GOT, GPT, Cu,Zn SOD and alkaline phosphatase enzyme activities in the serum which are related to the liver functions. Therefore, the above results suggest that Houttuynia cordata ethanol extracts can help to maintain normal liver functions and help to protect from peroxidative damages caused by excess dietary fat intake.

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