The Radioprotective Effect of Sam-Ryung-Baek-Chul-San (San-Ling-Bai-Shu-San) as a Prescriptions of Traditional Chinese Medicine in Irradiated Mice

방사선 피폭 마우스에서 삼령백출산 및 구성단미의 방호효과

  • Lee, Song-Eun (College of Veterinary Medicine, Chonnam National University) ;
  • Oh, Heon (College of Veterinary Medicine, Chonnam National University) ;
  • Yang, Jung-Ah (College of Veterinary Medicine, Chonnam National University) ;
  • Chung, Chi-Young (College of Veterinary Medicine, Chonnam National University) ;
  • Jang, Jong-Sik (Dept. of Animal Science, Sangju National University) ;
  • Jo, Sung-Kee (Food Irradiation Team, Korea Atomic Energy Research Institute) ;
  • Byun, Myung-Woo (Food Irradiation Team, Korea Atomic Energy Research Institute) ;
  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University)
  • 이송은 (전남대학교 수의과대학) ;
  • 오헌 (전남대학교 수의과대학) ;
  • 양정아 (전남대학교 수의과대학) ;
  • 정치영 (전남대학교 수의과대학) ;
  • 장종식 (상주대학교 축산학과) ;
  • 조성기 (한국원자력연구소 방사선식품공학팀) ;
  • 변명우 (한국원자력연구소 방사선식품공학팀) ;
  • 김성호 (전남대학교 수의과대학)
  • Published : 1999.04.01

Abstract

We performed this study to determine the radioprotective effect of Sam Ryung Baek Chul San (San Ling Bai Shu San), as a prescription of traditional Oriental medicine, and its major ingredients. Jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in irradiated mice with high and low dose of rays. Sam Ryung Baek Chul San administration before irradiation increased the formation of endogenous spleen colony(p<0.05) and reduced the frequency of radiation induced apoptosis(p<0.05). In the experiment on the effect of ingredients of Sam Ryung Baek Chul San, the result indicated that the extracts of Panax ginseng, Poria cocos and Coix lacryma jabi might have the major radioprotective effects. Although the mechanisms of these inhibitory effects remain to be elucidated, these results indicated that Sam Ryung Baek Chul San might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

Keywords

References

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