Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지

Effects of Garlic on the Blood Lipids and Other Serum Components in Rats

흰쥐에 마늘 투여로 혈액의 지질량과 그외 혈액성분 변화 고찰

  • 서화중 (조선대학교 식품영양학과)
  • Published : 1999.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

In present study possible hypolipidemic effects of garlic were investigated in an experimental model which consisted of 4 groups of Wistar rats(three weeks old): CO group received a basal diet(as a standard diet) contained 6.3% of corn oil. LO group was taken the experimental diet in which only 6.3% corn oil in basal diet was substituted by 12.6% of lard oil. So the experimental diet was somewhat high saturated fat diet. LG1 group was treated orally with garlic juice as 1% of raw garlic in the diet together with the same diet as the diet for LO group. LG2 group was taken 2% of garlic under the same dietary condition as that of LG1 group. The rat body weights prior and posterior to the experimental period were measured and the amount of the experimental dietary intake was determined at every 3 day interval. After the experimental dietary period of 30 days the blood obtained from all the sacrificed rats were analyzed for the biochemical parameters. Over the one month period of experiment there was no abnormality or apparent change in appearance and activity or diet consumption in all experimental rat groups. LO group fed a diet rich in lard showed significantly increased body weight gain rate by 30% and also elevated levels of triglyceride, total cholesterol and LDL cholesterol by 29.9%, 27.4% and 62.3% respectively and no significant difference in the levels of HDL cholesterol, GOT, GPT, blood glucose and blood urea nitrogen as compared to those of control group. So it seemed that the high calorie diet in LO group mainly contributed to the significant increase in body weight gain rate and other biochemical parameters. In spite of 1% garlic treatment LG1 group had significantly increased body weight gain rate by 25.2%, levels of triglyceride, total choesterol and LDL cholesterol by 25.2%, 24.6% and 50.5% respectively as compared to control and LO group, and no increase in the levels of HDL cholesterol, blood glucose and blood urea nitrogen. At garlic 1% diet there was no hypolipidemic efficacy in rat serum. Under the treatment with garlic 2% in diet LG2 group showed significantly increased body weight gain rate by 19.7% as compared to control and elevated levels of GOT, GPT and BUN by 85.8~96.4%, 127~148% and 88% respectively as compared to control, but LG2 group had significantly reduced levels of triglyceride, total cholesterol and LDL cholesterol as compared to LOand LG1 group. In present study there were no significant change in HDL cholesterol and blood glucose value. In LG2 group GOT, GPT and blood urea nitrogen values were slightly increased presumably due to the inhibiting effects of garlic on the hepatic or renal function of rats. Nevertheless in this study garlic may have some demonstrable hypolipidemic effects in rat.

Keywords

References

  1. Jeungbo Dongeubogam Huh,J.
  2. Dohae bonchogangmok Lee,S.J.
  3. J. R. Coll. Physicians, Lond. v.28 Garlic as a lipid lowering agent, a meta analysis Silagy,C.;Neil,A.
  4. Br. J. Clin. Pract. Symp. Suppl. v.69 Therapy with garlic : result of a placebo-controlled, double-blind study Vorberg,G.;Schneider,B.
  5. Br. J. Clin. Pract. Symp. Suppl. v.69 Hypertension and hyperlipidaemia : garlic helps in mild cases Auer,W.;Eiber,A.;Hertkorn,E.;Hoechfeld,E.;Koehrle,U.;Lorenz,A.;Mader,F.;Merx.W.;Otto,G.;Schmid,O.B.
  6. Arzneimittelforschung v.40 Treatment of hyperlipidaemia with garlic powder tablets. Evidence from the German Association of General Practitioners' multicentric placebo-centrolled double-blind study Mader,F.H.
  7. Lipids v.29 Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis Yu,Y.Y.;Shaw,M.Y.
  8. FEBS Letters v.261 Allicin a naturally occurring antibiotic from garlic, specically inhibits acetyl-CoA synthetase Focke,M.;Feld,A.;Lichtenthaler,K.
  9. Arzneimittelforschung v.41 Inhibition of cholesterol biosynthesis by a water-soluble garlic extract in primary cultures of rat hepaocytes Gebhardt,R.
  10. Indian J. Exp. Biol. v.30 Antidiabetic effects of S-allyl cysteine sulphoide isolated from garlic Allium sativum Linn. Sheela,C.G.;Augusti,K.T.
  11. Prostaglandins. Leukot. Essent. Fatty Acids v.49 Effects of a garlic-derived principle(ajoene) on aggregation and arachidonic acid metabolism in human blood platelets Srivastava,K.C.;Tyagi,O.D.
  12. Leukot, Essent. Fatty Acids v.53 Consumption of a garlic clove a day could be beneficial in preventing thromobosis Ali,M.;Thomson,M.
  13. Arzneimitelforschung v.43 Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subject Legnani,C.;Frascaro,M.;Guazzaloca,G.;Ludovici,S.;Cesarano,G.;Coccheri,S.
  14. Clin. Investig. v.71 Effects of grlic coated tablets in peripheral arterial occlusive disease Kiesewetter,H.;Jung,F.;Jung,E.M.;Blume,J.;Mrowietz,C.;Birk,A.;Koscielby,J.;Wenzel,E.
  15. Thromb. Res. v.75 A garlic derivative, ajoene, inhibits platelet deposition on severely dmaged vessel wall in an invivo porcine experimental model Apitz,C.R.;Badimon,J.J.;Badimon,L.
  16. J. Postgrad, Med. v.37 Effect of ingestion of raw garlic on serum cholesterol level, cltoing time and fibrinolytic activity in normal subjects Gadkari,J.V.;Joshi,V.D.
  17. Pharmacotherapy v.13 Can garlic lower blood pressure? A pilot study McMahon,F.G.;Vagas,R.
  18. J. Hypertension v.12 A meta analysis of the effect of garlic on blood pressure Silagy,C.A.;Neil,H.A.
  19. Thromb. Res. v.68 Effect of ajoene, the major antiplatelet compound from garlic on platelet thrombus formation Apitz,C.R.;Badimon,J.J.;Badimon,L.
  20. The laboratory rats v.Ⅱ Baker,H.J.;Lindsey,J.R.;Weisbroth,S.H.
  21. The clinical pathology The Assocition of Korean Clinical Pathology
  22. Experimental biochemistry Korean Biochemical Associaion
  23. Hangeul SPSS
  24. Am. J. Med. v.94 Can garlic reduce levels of serum lipids? A controlled clinical study Jain,A.K.;Vargas,R.;Gotzkowsky,S.;McMhon,F.G.
  25. Text book of medical physiology. (8th ed.) Guyton
  26. Text book of medicine Beeson,P.B.;McDermott,W.;Wyngaarden,J.B.
  27. Arzneimittelforschung v.42 Postprandial lipemia under treatment with Allium sativum. Controlled double-blind study of subjects with reduced HDL2-cholesterol Rotzsch,W.;Richter,V.;Rassoul,F.;Walper,A.
  28. Indian J. Exp. Biol. v.27 Toxic effects of garlic extract and garlic oil in rats Joseph,P.K.;Rao,K.R.;Sundaresh,C.S.
  29. Planta Medica v.52 Antihepatotoxic action of Allium sativum bullbs Hikino,H.;Tohkin,M.;Bukiso,Y.;Namiki,T.;Nishimura,S.;Takeyama,K.
  30. Toxicology (2nd ed.) Klaassen,C.D.;Doull,J.;Amdur,M.O.
  31. J. Korean Soc. Food Sci. Nutr. v.26 Effects of green tea catechin on liver 3-hydroxy-3-methylglutaryl CoA reductase activity and serum lipid levels in streptozotocin-induced diabeic rats Rhee,S.J.;Park,G.Y.
  32. J. Korean Soc. Food Nutr. v.20 Effects of glycosl sucrose on blood glucose, serum lipids and activities of carbohydrate hydrolysing enzymes in rats Chung,Y.J.;Ly,S.Y.;Ahn,K.H.
  33. J. Korean Soc. Food Nutr. v.25 A study on the body fat content and serum lipids in college students Lee,Y.J.;Song,K.H.
  34. J. Korean Soc. Food Sci. Nutr. v.28 The relationship between the life style and the status of serum lipids and antioxidant vitamins in university students Kwon,C.S.;Han,E.H.;Yoo,S.H.;Jang,H.S.
  35. Basic nutriion and diet therapy. (5th ed.) Corinne,H.R.;Emma,S.W.
  36. J. Korean Soc. Food Sci. Nutr. v.28 Effects of extract of pueraria radix on lipid metabolism in rats high fat diet Lee,J.S.;Lee,K.H.;Jedng,J.H.
  37. Ann. Intern. Med. v.119 Effects of garlic on total serum cholesterol. A meta-analysis[see comments] Warshafsky,S.;Kamer,R.S.;Sivak,S.S.
  38. Nor. Laegeforen v.111 Dietar supplementation in the treatment of hyperlipidemia Tidsskr. Tonstad,S.
  39. Atherosclerosis v.113 On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemia Simons,L.A.;Balasubranmaniam,S.;von Konigsmark,M.;Parfitt,A.;Simons,J.;Peters,W.
  40. Arzneimittelforschung v.42 comparision of the efficacy and tolerance of a garlic preparation vs. bezafibrate Holzgartner,H.;Schmidt,U.;Kuhn,U.
  41. Angewante, Chemie, A Journal of The Gesellschaft Deutsher Chemikal v.31 he organo sulfur chemistry of genus Alliumimplication for the organic chemistry of sulfur Block,E.
  42. J. R. Coll. Physician Lond. v.28 Garlic as a lipid lowering agent-meta analysis Silagy,C.;Schneider,B.
  43. Lipids v.28 Garlic supplementation and lipoprotein oxidation susceptibility Phelps,S.;Harris,W.S.
  44. J. Ethnopharmacol. v.29 Effect of Allium sativum on epididymal spermatozoa, estradioltreated mice and general toxicity al Bekairi,A.M.;Shah,A.H.;Qureshi,S.
  45. Neurosurgery v.26 Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion: a case report [see comments] Rose,K.D.;Croissant,P.D.;Parliament,C.F.;Levin,M.B.
  46. Korean J. Nutrition v.1 Histopathological and histochemical studies on the effect of garlic and garlic oil to the rats Ro,I.H.;Lee,S.Y.
  47. J. Med. Korean v.10 Comparative study of the allicin and arsenite on albino rats with special regard to the effects on body weight, hemoglobin nd hepatic histology Lee,Y.S.
  48. Planta Medica v.55 HPLC of-s-alk(en)yl-L-cysteine derivatives in garlic including guantitative determination of (+)-Sallyl-L-cysteine sulfoxide(allin) Ziegler,S.J.;Sticher,O.
  49. Planta Medica v.56 Quantitative determiantion of allicin and allin from garlic by HPLC Bernhard,I.;Georg,W.;Bernd,M.;Karl,K.