Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Antitumor Activity of Gamdutang Aqua-Acupuncture Solution

감두약침액의 암세포 성장 저해 효과

  • 조경희 (동국대학교 한의학대학 경혈학교실) ;
  • 한상훈 (동국대학교 한의학대학 경혈학교실) ;
  • 임종국 (동국대학교 한의학대학 경혈학교실) ;
  • 손윤희 (의과대학 약리학교실 및 난치병한양방치료연구센터) ;
  • 이임태 (의과대학 약리학교실 및 난치병한양방치료연구센터) ;
  • 남경수 (의과대학 약리학교실 및 난치병한양방치료연구센터)
  • Published : 1999.12.01
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Abstract

Gamdutang aqua-acupuncture solution (GAS), Gamdutang water-extracted solution (GWS) and Dae-Gamdutang aqua-acupuncture solution (DGAS) were prepared and tested for antitumor activities. It was shown to possess considerable toxicity toward various tumor cell lines. Concentration of 5 $\times$ and 10$\times$ of GAS resulted in more than 70% inhibition of growth in Ehrlich ascites tumor cells (EATC), Hepa1c1c7 and A549. GAS at concentrations of 5$\times$ and 10$\times$ revealed more than 60% inhibition in HeLa. GWS showed more than 50% inhibition of growth with EATC and HeLa at concentrations of 5$\times$ and 10$\times$, respectively. Toxicity assay with GWS in Hepa1c1c7 and A549 revealed that more than 80% inhibition of growth at the concentration of 5$\times$ and 10$\times$. In morphological study, the number of cells were decreased, and the shape of cells was round-form in EATC, Hepa1c1c7, A549, HeLa with GAS.

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