생명과학회지 (Journal of Life Science)

  • 제9권6호
  • /
  • Pages.659-664
  • /
  • 1999
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지

마우스의 간장과 혈청 지질농도에 미치는 타우린 및 오로트산의 영향

Effects of Taurine and Orotic Acid on Lipid Concentration of Hepatic and Serum in Mouse

  • 차재영 (동아대학교 생명자원과학대학 생명자원과학부) ;
  • 조영수 (동아대학교 생명자원과학대학 생명자원과학부)
  • 발행 : 1999.12.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Male mice (ddY strain) were fed with the chow diet containing 10% sucrose supplemented with orotic acid at the 1% level or/and taurine at the 5% levels for 14 days. The concentrations of triacylglycerol and cholesterol in the liver were significantly lower in the orotic acid group than the control group. When taurine and orotic acid were administered simultaneously, the concentrations of triacylglycerol and cholesterol in the liver were higher and lower, respectively, compared to the orotic acid group. The concentration of triacylglycerol in the serum was higher in the taurine group than that of the control or the orotic acid groups, and the simultaneous supplementation of orotic acid and taurine further enhanced. There were no significantly difference in body weight gain, diary food intake, and the concentrations of serum cholesterol and hepatic phospholipid. These results suggest that dietary taurine stimulated the increasion of hepatic triacylglycerol by orotic acid in mouse.

키워드

참고문헌

  1. J. Biol. Chem. v.234 Colorimetric assay methods for free and phosphorylated glyceric acids Bartlett, G. R.
  2. J. Clin. Chem. Clin. Biochem. v.24 Biochemical changes in liver and blood during liver fattening in rats Bogin, E.;Y. Avidar;M. Merom
  3. J. Biol. Chem. v.268 Transit and sorting of apolipoprotein B within the endoplasmic reticulum and golgi compartments of isolated hepatocytes from normal and orotic acid-fed rats Cartwright, I. J.;A. M. Hebbachi;J. A. Higgins
  4. Biosci. Biotechnol. Biochem. v.62 Association between hepatic triacylglycerol accumulation induced by administering orotic acid and enhanced phosphatidate phosphohydrolase activity in rats Cha, J.-Y;Y. Maeda;K. Oogami;K. Yamamoto;T. Yanagita
  5. Plant Food Human Nutr.(in submitted) Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats Cha, J.-Y.;Y.-S. Cho;I. Kim;T. Yanagita
  6. Agri. Chem. Biotec. v.39 Effect of ingested orotic acid on serum, liver and kidney lipid concentration in rats Cho, Y.-S;S.-H. Kim;J.-Y. Cha
  7. Korea J. Life Science v.6 Effect of dietary orotic acid on triacylglycerol metabolism in rats and mice Cho, Y.-S.;J.-Y. Cha
  8. Biometrics v.1 Multiple range and multiple F tests Duncan, D. B.;
  9. J. Nutr. v.110 Species Specificity in the metabolic consequences of orotic acid consumption Durschlag, R.P.;J. L. Robinson
  10. Clin. Clim. Acta v.22 A colorimetric method for estimating serum triglyceride Fletcher, M. J.
  11. J. Biol. Chem. v.226 A simple method for the isolation and purification of total lipids from animals tissues Folch, J.;M. Lees;G. H. Sloane-Starley
  12. J. Clin. Nutr. Gastroenterol. v.6 Plasma lipoproteins in suckling rats: effect of dietary nucleotides Garcia-Molina, V.;J. A. Aguilera;A. Gil;A. Sanchez-Pozo
  13. L. Dairy Res. v.48 Acid-soluble nucleotides of cow's, goat's and sheep's milks, at different stages of lactation Gil, A.;F. Sanchez-Medina
  14. Hepatocyte v.31 The effect of taurine on experimental fatty degeneration in primary cultured rat hepatocytes Hayashi, M.
  15. Biosci. Biotechnol. Biochem. v.57 Liver-specific induction of NADPH-generating enzymes by polycholrinated biphenyls in rats Hitomi, Y.;H. Wakayama;H. Oda;A. Yoshida
  16. J. Med. Sco. Toho, Japan v.38 A study of a new experimental model of fatty degeneration by cultured hepatocytes Ihara, F.
  17. Biosci. Biotechnol. Biochem. v.63 Effect of dietary taurine on endogenous hypercholesterolemia in rats fed on phenobarbital-containing diets Mochizuki, H.;j. Takido;H. Yokogoshi
  18. Pharmacolog. v.52 Hypolipidemic effect of taurine in stroke-prone spontaneously hypertensive rats Murakimi, S.;I. Yamagishi;Y. Ohta;Y. Toda;Y. Nara;Y. Yamori
  19. Jpn. J. PHarmacol. v.33 Pretreatment with carbon tetrachloride intoxication Nakashima, T.;T. Taniko;K. Kuriyama
  20. Eur. J. Pharmcol. v.180 The effects of taurine on atherosclerosis development in cholesterol-fed rabbit Petty, M. A.;J. Kintz;G. F. Difrancesco
  21. J. Dairy Sci. v.63 Bovine milk orotic acid : variability and significance for human nutrition Robinson, J. L.
  22. J. Biol. Chem. v.187 Averision of the Shoenheimer-Sperry method for cholesterol determination Sperry, W. M.;M. Webb
  23. Agric. Biol. Chem. v.53 Comparision between the plasma cholesterol-lowering effects of glycine and taurine in rats fed on high cholesterol diets Sugiyama, K.;A. Ohishi;Y. Ohnuma;K. Muramatsu
  24. J. Lipid Res. v.26 Early effects of dietary orotic acid upon liver lipid synthesis and bile cholesterol secretion in rats Tokmakjian, S. D.;D. S. M. Haines
  25. Ind. J. Biochem. v.5 Species specificity in orotic acid induced fatty liver Valli, E. A.;D. S. R. Sarma;P. S. Sarma
  26. Proc. Jpn. Conf. Biochem. Lipids v.38 Triglycerole metabolism of fatty liver and the prevention by dietary n-3 fatty acid Yanagita, T.;K. Oogami;K. Yamamoto;J.-Y. Cha;J. Nunez