Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of Ganoderma lucidum Extract on Memory and Oxidative Stress of Senescence-Accelerated Mouse

노화촉진마우스의 기억력 및 산화 스트레스에 미치는 영지 (Ganoderma lucidum) 추출물의 영향

  • 유제권 (한국화학연구소 안전성연구부 실험동물연구실) ;
  • 최선주 (한국화학연구소 안전성연구부 실험동물연구실) ;
  • 강종구 (충북대학교 수의과대학 실험동물의학 연구실) ;
  • 한상섭 (한국화학연구소 안전성연구부 실험동물연구실)
  • Published : 1999.10.01
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Abstract

Long-term effects of Ganoderma lucidum (GL) on memory and oxidative stress of senescence-accelerated mice (SAM) were investigated. Senescence-resistant (R1) and prone (P8) strains of SAM were fed GL diets, premixed with low (20 mg/kg/day, T1) or high (200 mg/kg/day, T2) levels of GL powder for 9 months starting from young (3 months of age) or for 5 months starting from old (7 months of age). After the final feeding at 12 months of age, all animals were subjected to passive avoidance test for the evaluation of memory function. In addition, the changes in hepatic thiobarbituric acid-reactive substance (TBARS) and glutathione were analyzed. SAMP8 fed GL diets from old age (7 months) exhibited the improvement of memory, although GL rather inhibited the memory function of both SAMR1 and SAMP8 mice fed diets from young (3 months of age). Hepatic TBARS contents were decreased in SAMP8 fed high GL diet for 9 months and in SAMR1 fed low GL diet for 5 months. Hepatic glutathione content was also remarkably increased in SAMR1 following both feeding periods, and less extent in SAMP8 fed diet for 5 months of age. Taken together, it is proposed that GL extracts may play an anti-aging role through antioxidant action, and thereby may improve the senescence-related memory dysfunction.

Keywords

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