Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
권호 표지

Effects of Sea Tangle (Laminaria japonica) and Fucoidan Components on Chronic Degenerative Diseases

만성퇴행성 질환에 미치는 다시마(Laminaria japonica)와 후코이단 성분의 영향

  • 최진호 (부경대학교 식품생명공학부 생화학연구실) ;
  • 김대익 (부경대학교 식품생명공학부 생화학연구실) ;
  • 박수현 (부경대학교 식품생명공학부 생화학연구실) ;
  • 김동우 (부경대학교 식품생명공학부 생화학연구실) ;
  • 이종수 (부경대학교 식품생명공학부 생화학연구실) ;
  • 유종현 (한림제약(주) 중앙연구소) ;
  • 정유섭 (한림제약(주) 중앙연구소)
  • Published : 1999.08.01
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Abstract

This study was designed to investigate the effects of sea tangle (Laminaria japonica) extract and fucoidan components on chronic degenerative diseases. Sprague-Dawley(SD) male rats (210$\pm$5g) were fed experimental diets: Dasi-Ex group: dasima extract powder of 4.0% added to control diet; Fuco-I, II and III groups: fucoidan powder of 1, 2 and 3% added to Dasi-Ex group for 45 days. Triglyceride (TG) levels in serum were significantly lower (10~15%) in Fuco-I, II and III groups compared with control group. Total cholesterol levels were significantly decreased (7~10% and 15~ 35%) in brain mitochondria and microsomes of Fuco-II and III group compared with control group. LDL-cholesterol levels were remarkably decreased (20~30%) in Dasi-Ex and Fuco-I, II, III groups, but HDL-cholesterol levels were significantly increased (10~12%) in Fuco-II and III groups only compared with control group. The ratios of HDL/total cholesterol resulted in a marked increase (3 5~55%) in Dasi-Ex and Fuco-I, II, III groups, but atherogenic indices were remakably decreased (40~50%) in Dasi-Ex and Fuco-I, II, III groups compared with control group. Membrane fluidities were remarkably increased (45~70% and 38~42%, respectively) in brain mitochondria and microsomes of Fuco-II and III groups compared with control group. Administrations of fucoidan added to dasima effectively decreased TG, total and LDL-cholesterol, and atherogenic index, while also effectively increased HDL-cholesterol, HDL/total cholesterol ratio, and membrane fluidity, suggesting chronic degenerative diseases were very effectively prevented by the administration of fucoidan component.

Keywords

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