Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of Hesperetin and Naringenin on Lipid Concentration in Orotic Acid Treated Mice

오르트산 투여 마우스의 지질농도에 미치는 Hesperetin 및 Naringenin의 영향

  • 차재영 (동아대학교 생명자원과학대학 생명자원과학부) ;
  • 김석영 (안동과학대학 식품과학과) ;
  • 정순재 (동아대학교 생명자원과학대학 생명자원과학부) ;
  • 조영수 (동아대학교 생명자원과학대학 생명자원과학부)
  • Published : 1999.08.01
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Abstract

Male mice (ddY strain) were fed a laboratory chow diet containing 10% sucrose supplemented with orotic acid, hesperetin or naringenin at the 1% level for 14 days. the concentrations of liver triacylglycerol and cholesterol were significantly lower in the OA group than in the control group. When both flavonoids and orotic acid were administered simultaneously, the orotic acid-dependent decrease in liver triacylglycerol and cholesterol were attenuated slightly. The concentration of serum cholesterol in the orotic acid group or the control group was lower than in the orotic acid groups supplemented with hesperetin or naringenin. There were no significantly difference in body weight gain, diary food intake, and the serum concentrations of triacylglycerol and high-density-lipoprotein cholestrol. It was concluded that the inducement of fatty liver in mice failed to feeding a laboratory chow diet containing 10% sucrose supplemented with 1% orotic acid for 14 days.

Keywords

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