생명과학회지 (Journal of Life Science)

  • 제9권4호
  • /
  • Pages.375-381
  • /
  • 1999
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지

사염화탄소에 의해 유발된 생쥐의 간독성에 미치는 누에 추출물의 영향

Effects of Bombyx mori Larvae Extracts on Carbon Tetrachloride-Induced Hepatotoxicity in Mice

  • 류강선 (농업과학기술원 잠사곤충부) ;
  • 이희삼 (농업과학기술원 잠사곤충부) ;
  • 김선여 (경희대학교 동서의학 대학원)
  • 발행 : 1999.08.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

To evaluate the protective effects of extracts of silkworm on carbon tetrachloride-induced hepatotoxicity, serum glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase and lactic dehydrogenase activities, malondialdehydes values and glutathione-S-transferase activity were measured in ICR mice. Extracts of silkworm was administered orally at 30min after the administration of CCl4 Mice were sacrificed at 24h after the administration of extracts of silkworm. The activities of serum aminotransferase and the hepatic content of lipid peroxide after carbon tetrachloride treatment were markedly increased than normal control but those levels were decreased by the treatment of butanol soluble fraction of silkworm methanol extract. Glutathione S-transferase activity was decreased by carbontetrachloride than control, but also inhibited by the treatment of butanol soluble fraction of silkworm methanol extract.

키워드

참고문헌

  1. Laboratory technique in biochemistry and molecular biology v.21 Berry, M. N.;Edward, A. M.;Barritt, G. J.;Burdon(ed)
  2. Bichem. Pharmacol v.35 The crucial role of oxygen partial pressures in haloalkane free radical mediated lipid peroxidation Groot, H.;Noll, T.
  3. J. Biol. Chem. v.249 Glutathione S-transferases Habig, W. H.;Pabst, M. J.;Jakoby, W> B.
  4. Trends Genetics v.7 Integrated map of Drosophila genome Kafatos, F. C.;Louis, C.;Savakis, C.;Glover, D. M.;Ashurer, E.
  5. Planta Med. v.49 Assay method for antihepatotoxic activity using carbon tetrachloride induced cytotoxicity in primary cultured hepatocytes Kiso, Y.;Tohkin, M.;Hikino, H.
  6. Kyunghee Univ. Oriental Medi Proced v.10 Effects on glucose level in alloxan induced hypergylcemia rabbits Kwon, Y. C.;Kim, Y. S.;Bae, H. S.
  7. Lipids v.15 Lipid peroxidation Logani, M. K.;Davis, R. E.
  8. J. Biol. Chem. v.193 Protein measurement with the folin phenol reagent Lowry, O. H.;Rosebrough, N. J.;Farr, A. L.;Randall, R. J.
  9. Biochem. Pharmacol v.21 Effect of 3-methylchloanthrene induction on the $CCl_4-induced$ changes in rat hepatic microsomal enzyme system Maynard, E. H.;Bitterns, S.;James, R. G.
  10. Ann. Rev. Pharmacol. Toxicol v.25 The regulation as hepatic glutathione Naei, K.;Tak, Y. A.;Murad, O.
  11. Agricultural Chemistry and Biotechnology v.41 no.2 Cytotoxic activity of Bombyx mori and Morus alba derived materials against human tumor cell lines Park, I. K.;Lee, J. O.;Lee, H. S.;Seol, K. Y.;Ahn, Y. J.
  12. Pharmacol. Rev. v.19 Carbon tetrachloride hepatotoxity Recknigel, R. O.
  13. Am. J. Clinic. Pathol v.28 A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyrivic transaminase Reitman, S.;Frankel, S.
  14. J. Natl. Prod. v.55 no.9 Characterization of silkworm chlorphyll metabolites as an active photosensitizer for photodynamic therapy Renke, D.;Richard, S.;David F.;Han. H. J.;Kim, C. S.;Song, P. S.
  15. Biochemistry v.12 Insect growth regulator, Comprehensive insect physiology Retnakaran, A.;Granett, J.(et al.)
  16. Rural Development Administration Studies on the Development of functional foods from silkworm related materials Ryu, K. S.;Chung, S. H.
  17. Silkworm and Diabetes Ryu, K. S.;Chung, S. H.