Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of Pefloxacin Grinding on Pharmacokinetic Parameter in Korean Rockfish

조피볼락에서 Pefloxacin의 미분쇄가 약물동력학 Parameters에 미치는 영향

  • Published : 1999.06.01
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Abstract

Antibiotics have been routinely used to control the disease of farm-raised animals in the aquaculture facilities without any criterion based on a pharmacokinetic study. This lack of information on the effective usage of antibiotics would have brought the farmers to use excessive and/or less dosages, causing the advent of drug-resistant bacteria as well as economic loss and possible contamination of the local farming area. Until recently, few studies on a detailed manual for the antibiotic usage including chemotherapy procedure, dosage, and treatment schedule of the aquatic antibiotics have been conducted throughout the world. To the worse, there is no available criterion for optimal usage of aquatic antibiotics to control diseases in aquatic farms in this country because every country has its own aquacultural system. Therefore, based on the previous studies on the usage of the various antibiotics, our studies are to focus on the development of optimal method for the detection of various antibiotics on the fate of antibiotics applied to the fish, including absorption, circulation, and secretion physiology. Pharmacokinetic study were to sep up the optimal detective condition against residual antibiotics of fish by HPLC. The grinding pefloxacin for 15 min is most effective in dissolution test and pharmacokinetic parameters. Pharmacokinetic parameters were satisfactory for 15 min-grinding products and they can be explained as one-compartment model.

Keywords

References

  1. Am. J. Vet. Res. v.56 no.4 Pharmacokinetics of enrofloxacin in Chicken Anadon, A.;Marrinez-Larranaga, M.R.;Diaz, M.J.
  2. J. Pharmaceutical Sciences v.73 no.10 Dose Dependent Pharmacokinetic Study of Pefloxacin, A New Antibacterial Agent, in Humans Barre, J.;Houin, G.;Tillement, J.P.
  3. The Merck Index(12th Ed.) Budavari, S.
  4. J. Pharmaceutical Sciences v.69 High-performance liquid chromatographic assay for chloramphenicol, chloramphenicol-3-monosccinate and chloramphenicol-1- monosccinate Burke, J.T.;Wargin, W.A.;Blum, M.R.
  5. J. Soc. Powder Technol. Japan v.33 no.9 Grinding rate Improvement Using a Composite Griding Ball Size for an Ultra-fine Grinding Mill Choi, W.S.
  6. The Proceedings of 3rd World Congress on Particle Technology v.74 Grinding rate Improvement Using a Composite Grinding Ball Size for an Ultra-fine Grinding Mill-Applications of Grinding Kinetics Analysis Choi, W. S.
  7. J. Antimicrobial Chromatography v.14 Pefloxacin in rabbits;protein binding, extravascular diffusion, urinary excretion and bactericidal effect in experimental endocarditis Contrepois, A.;Daldoss, C.;Pangon, B.;Garaud, J.J.;Kecir, M.;Sarrazin, C.;Vallois, J.M.;Carbon, C.
  8. Korean J. Vet. Res. v.34 no.1 A Study on efficacy and safety of antibacterial(pefloxacin methanesulfonate) to cultured fish, Syprinus caprio and Paralichthys olivaceus Heo, G. J.:Kim, J.H.
  9. J. Chromatography B Biomed. Appl. v.653 no.1 Simulmneous determination of benofloxacin, enrofloxacin and ofloxacin in chicken tissue by high performance liquid chromatography Horrie, M.;Saito, K.;Nose, N(et al.)
  10. J. Pharmaceutical Sci. v.85 no.2 Transdermal Derlivery of Dide-oxynucleoside-Type Anti-HIV Drugs 2. The Effect of Vehicle and Enhancer on Skin Permeation Kim, D. D.;Yie W. Chein
  11. J. Agic. Food Chem. v.38 Method for isolation and liquid chromatographic determication of chloramphenicol in Milk Long, A.R.;Hsi, L.C.;Bello, A.C.;Malbrough, M.S.;Short, C.R.;Baker, S.A.
  12. J. Chromatography v.502 Method for the isolation and liquid chromatographic of eight sulfonamides in Milk Long, A.R.;Short, C.R.;Barker, S.A.
  13. J. Chromatography v.272 High Performance Liquid Chromatography of Pefloxcin and Its Main Active Metabolites in Biological Fluids Montay, G.;Blain, Y.;Roquet, F.;A. Le Hir
  14. Fisheries Seience v.61 no.2 Pressrvation od non sopre forming test organisms for a simplified bioassay by freezing and freeze-drying Ueno, R.;Kawahara, S.;Aoki, T.
  15. Nippon Suisan Gakkaishi v.54 no.3 Levels of Oxolinic Acid in cultured Rainbow Trout and Amago Salmon afterv Oral Administraion Ueno, R;Okumra, M.;Horiguchi, Y.;Kubota, S.S.
  16. Nippon Suisan Gakkaishi Determination of Oxytetracycline in Fish Tissues by High Performance Liquid Chromatography Ueno, R.;K.Uno, S.;Kubota, S.;Horiguchi, Y.
  17. 수진사업보고서(증양식분야) 수산용약제연구 1994 김진우;최동림;심두생;서상복
  18. 분체와 공업 v.27 no.8 Griding in the Preparation of Dosage Forms Yamamoto, K.
  19. 수진사업보고서(증양식분야) 수산용약제연구 1998 약리실(엮음)
  20. 食衛誌 v.25 no.5 高速液體クロマトダラスイ-による食肉中のテトラサイクリン系抗生物質及びマクロライド系抗生物質の定量 星野庸二;堀江正一;能勢憲英;岩崎久夫
  21. 食衛誌 v.30 no.1 高速液體クロマトダラスイ-による食肉中のテトラサイクリン系抗生物質の定量 木田 豊;古城典子;安藤良吉
  22. 生物藥劑學과 藥物速度論(再版) 李民和;具永順