Journal of Life Science
- 제9권1호
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- Pages.90-92
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- 1999
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- 1229-1552(pISSN)
A Misfolded Thyroglobulin is Retained by Molecular Chaperones in the Endoplasmic Reticulum
- Kwon, O-Yu (Department of Readiologic Technology, Taegu Health College) ;
- Seong, Yeon-Mun (Department of Anatomy and Internal Medicine, College of Medicine, Chungnam National University) ;
- Shong, Min-Bo (Department of Anatomy and Internal Medicine, College of Medicine, Chungnam National University)
- 발행 : 1999.06.01
초록
Deficient thyroglobulin is one of the important causes of congenital hypothyroid goiter with a prevalence of -1/40,000 humans. We now demonstrate that in cog/cog mice showing hypothyroidism, four endoplasmic reticulum-molecular chaperones stably bind to thyroglobulin, providing insight into physiologic regulation of endoplasmic reticulum storage diseases.