약학회지 (YAKHAK HOEJI)

  • 제43권5호
  • /
  • Pages.682-688
  • /
  • 1999
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

흰쥐를 이용한 에페드린의 약물남용가능성 평가

Evaluation on the Abuse Liability of Ephedrine Using Rats

  • 류승렬 (식품의약품안전청 국립독성연구소) ;
  • 김혜진 (식품의약품안전청 국립독성연구소) ;
  • 홍진태 (식품의약품안전청 국립독성연구소) ;
  • 이종권 (식품의약품안전청 국립독성연구소) ;
  • 이선희 (식품의약품안전청 국립독성연구소) ;
  • 이병무 (성균관대학교 약학대학) ;
  • 김부영 (식품의약품안전청 국립독성연구소)
  • 발행 : 1999.10.01
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초록

Abuse liability of ephedrine was investigated by measurement of locomotor activity and self-administration in Sprague-Dawley rats. Locomotor activity was determined in rats treated with 3, 10 and 30 mg/kg ephedrine for 14 days. Self-administration by ephedrine (0.23, 1 and 2.3 mg/kg) was examined in food-trained rats. We also examined effect of dopamine receptor antagonist (spiperone, $30{\;}\mu\textrm{g}/kg$) on the ephedrine-induced response of self-administration. Body weight was not statistically difference between control and ephedrine treatment group, but locomotor activity was dose-dependently increased. Self-administration for ephedrine was decreased in the early response (day 1 and 2) but the response was increased by higher dose of ephedrine. Self-administration was decreased by dopamine receptor antagonist (spiperone). These data showed that ephedrine increased locomotor activity and induced response of self-administration, and the effects of ephedrine were partially related to the dopaminergic system, which suggest the ephedrine may have abuse liability.

키워드

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