YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Determination of Basic Drugs with Ion-Selective Membrane Electrodes Using Ion-Exchanger

이온교환체 이온선택성 전극을 이용한 염기성의약품 정량

  • Published : 1999.06.01
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Abstract

Many poly (vinyl chloride : PVC) membrane electrodes were investigated for the determination of basic drugs, chlorpromazine, amitriptyline, nortriptyline, etc. These electrodes are based on the use of the ion-association complexes of the basic drugs with eriochrome cyanine R, chromoxane cyanine, chrome azurol S and picric acid as ion-exchange sites in a plasticized PVC matrix. All ion-exchangers except picrate complex were not proper for use, because those complexes in plasticized membrane were excluded into aqueous working solution. These drug electrodes show excellent Nernstian responses in the concentration ranges $10^{-2}~10^{-6}$ mol $dm^{-3}$. Their selectivity with respect to each other, as well as their work-able pH range have been investigated. The major advantages of the proposed methods are their simplicity and speed.

Keywords

References

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