Archives of Pharmacal Research
- Volume 22 Issue 3
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- Pages.302-305
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- 1999
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of 4-Hydroxy-1-thiocounmarin Derivatives-1 : An Efficient Synthesis of Thioflocoumafen
- Jung, Jae-Chul (Department of Chemistry, Chungbuk National University) ;
- Kim, Ju-Cheun (Department of Chemistry, Chungbuk National University) ;
- Park, Oee-Sook (Department of Chemistry, Chungbuk National University) ;
- Jang, Bong-Suek (Department of Chemistry, Chungbuk National University)
- Published : 1999.06.01
Abstract
An efficient procedure for the preparation of 4-hydroxy-3-{1,2,3,4-tetra-hydro-3-[4-(4-trifluoromethylbenzyloxy)phenyl]-1-naphthyl}thiocoumarin (thioflocoumafen, 1a and 1b) is described. The key step in the synthesis involves the condensation reaction of 3-(4-methoxyphenyl)-1-tetralol (2) with 4-hydroxy-1-thiocoumarin (3).