YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Comparative Effects of $Ca^{2+}$ Antagonists and Protein Kinase Inhibitors on Rat Aorta Contraction Induced by KCI and Phenylephrine

KCI과 phenylephrine에 의한 대동맥 수축에서 $Ca^{2+}$ 길항제와 protein kinase 억제제들의 비교 효과

  • Published : 1999.10.01
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Abstract

To investigate the difference of contractile mechanism between KCI and phenylephrine-induced contraction, we observed effects of $Ca^{2+}$ antagonists and protein kinase inhibitors on aorta contraction of rats. Verapamil dose-dependently inhibited the contraction induced by KCI and phenylephrine, the inhibitory effect of verapamil was more potent in KCI-induced contraction than phenylephrine-induced contraction. Econazole and TMB-8 significantly inhibited CKI-induced contraction but did not inhibit phenylephrine-induced contraction. Staurosporine dose-dependently inhibited both KCI and phenylephrine-induced contraction. Genistein and calmodulin antagonists (W-7 and trifluoperazine) also inhibited both contraction in a dose dependent manner. However, the inhibitory effects of genistein and calmodulin antagonists were more potent in phenylephrine-induced contraction than KCI-induced contraction. These results suggest that involvements of $Ca^{2+}$ channel and protein kinase in rat aorta contraction were dependent on agonist causing aorta smooth muscle contraction.

Keywords

References

  1. Proc. Natl. Acad. Sci. (USA) v.81 Pharmacomechanical coupling in smooth muscle may involve phosphatidylinositol metabolism Baron, C. B.;Cunningham, M.;Strauss III;J. F. Coburn, R. F.
  2. J. Biol. Chem. v.261 Carbachol induces a repid and sustained hydrolysis of polyphosphoinositide in bovine tracheal smooth muscle measurement of the mass of polypho-sphoinositides, 1,2-diacylglycerol, and phosphatidicacid Takuwa, Y.;Takuwa, N.;Rasmussen, H.
  3. Biochem. Pharmacol. v.36 Polyphosphoinositide metabolism in canine tracheal smooth muscle (CTSM) in response to a cholinergic stimulus Duncan, R. A.;Krzanowski, J.J.;Davis, J. S.;Polson, J. B.;Coffey, R. G.;Shimoda, T.;Szentivanyi, A.
  4. Scand.J.Gastroenterol. v.28 H1 receptor mediates inositol phophates response to histamine in gastric smooth muscle of guinea pigs Sim, S. S.;Jo, Y. H.;Hahn, S. J.;Yoon, S. H.;Rhie, D. J.;Kim, M. S.
  5. Proc. Natl. Acad. Sci. (USA) v.82 Inositol trisphosphate-induced calicium release adn contraction in vascular smooth muscle Somlyo, A. V.;Bond, M.;Somlyo, A. P.;Scarpa, A
  6. Am. J. Physiol. v.260 Simultaneous measurement of membrane potential cytosolic $Ca^2+$, and tension in intact smooth muscles Ozaki, H.;Stevens, R. J.;Blondfield, D. P.;Puvlicover, N. G.;Sanders, K. M.
  7. Br. J. Pharmacol. v.114 $Ca^2+$ entry activated by emptying of intracellular $Ca^2+$ stores in ileal smooth muscle of the rat Ohta, T.;Kawai, K.;Ito, S.;Nakazato, Y.
  8. Am. J. Physiol. v.260 Relationship between calcium current and cytosolic calcium in canine gastric smooth muscle cells Vogalis, F.;Publicover, N. G.;Hume, J. R.;Sanders, K. M.
  9. Br. J. Pharmacol. v.114 Effects of semotiadil fumarate, a novel $Ca^2+$ antagonist, on cytosolic $Ca^2+$ level and force of contraction in porcine coronary arteries Kageyma, M.;YAnagisawa, T.;Taire, N.
  10. Circ. Res. v.61 Two types of calcium channels in single smooth musle cells from rabbit ear artery studied with whole-cell and single-channel recordings Benham, C. D.;Hess, P.;Tsien, R. W.
  11. Life Sci v.49 The direct contractile effect of gastrin releasing peptide on isolated gastric smooth muscle cells of the guinea pig Chijiiwa, Y.;Harada, N.;Misawa, T.;Yoshinaga, M.;Kabemura, T.;Nawata, H
  12. Eur. J. Pharmacol. v.234 Effects of feldipine, nifedipine and verapamil on cytosolic $Ca^2+$ and contraction in vascular smooth muscle Hagiwara, S.;Mitsui, M.;Karaki, H.
  13. Eru.J. Pharmacol. v.275 The involvement of protein kinase C in the contraction of human ariway smooth muscle Yang, K.X.F.;Black, J.L.
  14. Am. J. Physiol. v.260 Intracellular pathways for contraction in gastroesophageal smooth muscle cells Hillemeier, C.;Bitar, K. N.;Marshall, J. M.;Biancani, P
  15. Can. J. Physiol. Pharmacol. v.72 Tyrosine kinase inhibitors and the contractile action of G-protein-linked vascular agonists Laniyonu, A. A.;Saifeddine, M.;Yang, S. G.;Hollenberg, M. D.
  16. Eur. J. Pharmacol. v.277 $α_2$-Adrenoceptor-mediated vasoconstriction requires a tyrosine kinase Jinsi, A.;Deth, R. C.
  17. Nature v.308 The role of protein kinase C in cell surface signal transduction and tumor promotion Nishizuka, Y.
  18. J. Biol. Chem. v.266 Endothelin, vasopressin and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesengial cells Force,T.;Kyriakis, J.M.;Avruch,J.;Bonventres,J. V.
  19. TIPS v.13 Receptor sites for $Ca^2+$ channel antagonists Catterall, W.A.;Striessnig, J.
  20. Am. J. Physiol. v.264 Inhibition of $Ca^2+$ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365 Mason, M.J.;Mayer,B.;Hymel,L.J.
  21. Biochem.J. v.274 Cytochrome P-450 may link intracellular $Ca^2+$stores with plasma membrane $Ca^2+$ influx Alvarez, Z.;Montero, M.;Gaecia-Sancho, J
  22. Eur. J. Pharmacol. v.197 Inhibitory effect of 8(N,N-diethylamino) octyl-3,4,5-trimethoxyben-zoate(TMB-8) in vascular smooth muscle Ishihara, H.;Karaki, H.
  23. Kor. J. Gastroenterol. v.32 Regulation of protein kinase in KCL-induced contraction of cat gastric smooth muscle Sim, S. S.;Kim, S. R.;Shim, H. S.;Rhie, D. J.;Hahn, S. J.;Yoon, S. H.;Jo, Y. H.;Kim, M. S.