YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antitumor and Antileukopenic Activity of HCA, the Protein-polysaccharide Fraction of Cultured Mycelia of Hebeloma crustuliniforme

무자갈버섯 (Hebeloma crustuliniforme) 배양 균사체로부터 분리한 단백다당체 분호기 HCA의 항암 및 백혈구감소증 억제효과

  • 조경주 (충남대학교 약학대학 미생물면역학교실) ;
  • 정경수 (충남대학교 약학대학 미생물면역학교실)
  • Published : 1999.10.01
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Abstract

A protein-polysaccharide fraction was isolated from the mycelial culture of a Korean basidiomycetous fungus, Hebeloma crustuliniforme, and was named HCA (Hebeloma crustulineforme fraction A). When intraperitoneally injected at 200 mg/kg/day once daily for 10 days, HCA inhibited the growth of sarcoma 180 solid tumor in ICR mice by 65.1% (p＜0.05). HCA also exerted protective effect against leukopenia induced by cyclophosphamide with the protection ratio of 39.7% (p＜0.01).

Keywords

References

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