YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Corrosolin and Compound-2: Cytotoxic Annonaceous Acetogenins from the Seeds of Annona cherimolia

Corrosolin 및 Compound-2 : Annona cherimolia 씨앗으로부터 분리된 세포독성 Annonaceous acetogenin

  • 김달환 (대구효성가톨릭대학교 약학대학) ;
  • 우미희 (대구효성가톨릭대학교 약학대학)
  • Published : 1999.10.01
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Abstract

Bioactivity-directed fractionation from the seeds of Annona cherimolia resulted in the isolation of two known cytotoxic compounds : corrosolin (1) and compound-2 (2). The structures of these compounds were characterized on the basis of chemical and spectral data. Corrosolin has a relative stereochemical relationship of threo/trans/threo for the mono-tetrahydrofuran (THF) ring with two flanking hydroxyls, from C-15 to C-20, which is the annonacin type. Compound-2 has a relative stereochemical relationship of threo/trans/threo/trans/threo for the adjacent bis-THF ring with two flanking hydroxyls, such as in the asimicin type. The absolute configurations of carbinol carbons in corrosolin in corrosolin were determined as 10R, 15R, and 20R by analysis of its Mosher ester derivatives. Corrosolin and compound-2 are known, but are first isolated in this plant.

Keywords

References

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