YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Protective Effects of the Phenolic Compounds from the Leaves of Hedera rhombea on Hepatic Injury

송악의 페놀성 물질의 간 보호효과

  • 김경숙 (이화여자대학교 약학대학 약학과) ;
  • 송지영 (원자력 병원 면연학 연구실) ;
  • 이인란 (이화여자대학교 약학대학 약학과)
  • Published : 1999.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

Hedera rhombea (HR) has been used for treatments of hemorrage, chronic catarrh, jaundice, lithisis and convulsion. This study was done to isolate active compounds that have protective effect on liver damage. BuOH and EtOAc fractions of HR recovered serum glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT) and ${\gamma}-glutamyltranspeptidase$ (${\gamma}-GTP$) activities in CCl4 treated rats. We isolated 7 phenolic compounds from BuOH and EtOAc fractions, which were identified as 3-caffeoyl quinic acid, 3,4-di-O-caffeoyl quinic acid, 3,5-di-O-caffeoyl quinic acid, 4,5-di-O-caffeoyl quinic acid, caffeic acid, methyl 3,4-di-O-caffeoyl quinic acid and methyl 3,5-di-O-caffeoyl quinic acid by chemical and spectral analysis. These compounds reduced significantly serum GOT and GPT elevated by CCl4 treatment in rats, and 3-caffeoyl quinic acid, 3,5-di-O-caffeoyl quinic acid and caffeic acid also showed mild inhibitory activity against human immunodeficiency virus.

Keywords

References

  1. 한국식물도감 식물편(목초본) 정태현
  2. 한국자원식물 송주택
  3. 향약대사전(식물편) 정보석;신민교
  4. 中藥大辭典(中編) 新文豊出版公司
  5. 中藥大辭典(下編) 江蘇新醫學阮
  6. Pharmazie v.43 Spermicidal glycosides from H. nepalensis K. Koch (Inflorescence) Pant, G.;Panwar, M. S.;Rawat, M. S.;Negi, D. S.
  7. 榮田承二
  8. Koeran J. Pharmacognosy v.23 Pharmacological activities of the leaves of hedera rhombea bean Lee, I. R.;Kim, J. S.;Lee, S. H.
  9. Arch. Pharm. Res v.20 A novel nortriterpene from Hedera rhombea Kim, K. S.;Choi, Y. H.;Lee, I. R.
  10. Arch. Pharm. Res v.16 no.4 Pharmacological activities and the consitiuents of the leaves of Hedera rhombea (Ⅱ): On the constituents of the leaves Lee, I. R.;Lee, M. S.;Choi, K. A.;Seo, E. K.
  11. Chem. Pharm. Bull v.33 Studies on Nepalese crude drugs. Ⅲ. On the saponins of Hedera nepalesis Kizu, H.;Koshijima, H.;Tomimori, T.
  12. Am. J. Cln. Pathol v.28 A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase Reitmann, S.;Frankel, S.
  13. Clin. Chem v.14 The determination of triglyceride in plasma and tissuse Sardea, V. M.;Manning, J. A.
  14. J. Lab. and Clin. Med v.50 Micromethod for the determination of serum triglyceride Van Handel E.;Zilversmit D. B.
  15. J. Inf. Dis v.141 Comparative efficatcy of antiherpes drugs against different strains of herpes simplex virus Clercq, E. De.;Descamps, J.;Verhesst, G.;Walker, R. T.;Jones, A. S.;Torrence, P. E.;Shugar, D.
  16. Doctoral Thesis,KyuShu University Chemical Studies on Tannin and its related compounds of M. japonicus, M. repandus and M. philippinesis, Euphorbiaceae Saizo, Reiko
  17. Phytochemistry v.30 Quinic acid esters from Iseria haenkeana Rumbero-Sanchez, A.;Vazquez, P.
  18. J. Chromatogr v.315 Chromatographic separation and identification of naturally occurring chlorgenic acids by $1^H$nuclear magnetic resonance spectroscopy and mass spectrometry Morishita, H.;Iwahashi, H.;Osaka, N.;Kido, R.
  19. Biol. Pharm. Bull v.19 Potent antiepatotoxic acticity of dicaffeoy quinic acids from propolis Shigetoshi, R.;Tsuneo, N.
  20. J. Nat. Prod v.46 Constituents of Chrysothammnus paniculatus 3, 3, 4, 5-tricaffeoylquinic acid (A new shikimate prearomatic) and 3, 4-, 3, 5,-and 4, 5-dicaffeoyl quinic acids Timmermann, B. N.;Hoffmann, J. J.;Jolad, S. D.;Scharm, K. H.;Klenck, R. E.;Bates, R. B.
  21. J. Org. Chem v.41 The polyphenolic acids of Lithospermum ruderale Ⅱ. Carbon-13-nuclrear magnetic resonance of lithospermic and rosmarilnic acids Kielley, C. J.;Harruff, R. C.