YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Studies on the Effects of Evodiae Fructus on the Cardiovascular System in N-nitro-L-arginine Methyl Ester-induced Hypertensive Wistar Rats

오수유가 N-nitro-L-arginine methyl ester로 유발한 고혈압흰쥐의 심혈관계에 미치는 영향

  • 정수연 (식품의약품안전청 국립독성연구소 약리부) ;
  • 이숙영 (식품의약품안전청 국립독성연구소 약리부) ;
  • 유태무 (식품의약품안전청 국립독성연구소 약리부) ;
  • 안미령 (식품의약품안전청 국립독성연구소 약리부) ;
  • 최현진 (식품의약품안전청 국립독성연구소 약리부) ;
  • 정면우 (식품의약품안전청 국립독성연구소 약리부) ;
  • 류항묵 (식품의약품안전청 국립독성연구소 약리부) ;
  • 양지선 (식품의약품안전청 국립독성연구소 약리부)
  • Published : 1999.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

The present study examined the effect of a methanol extract of Evodiae Fructus on the cardiovascular function in N-nitro-L-arginine methyl ester (NAME)-induced hypertensive Wistar rats after treatment over 6 weeks. In rats treated with NAME, blood pressure, weight of heart, aorta media thickness and media/lumen ratio significantly (p<0.05) increased, whereas coronary flow and heart rate of isolated heart significantly (p<0.05) decreased compared with control group at 6 weeks. In rats treated with NAME and Evodiae Fructus, blood pressure, aorta media/lumen ratio significantly(p<0.05) decreased compared with NAME treated group at 6 weeks. These results suggest that Evodiae Fructus is applicable to the treatment of hypertension and vascular hypertrophy.

Keywords

References

  1. 아세아생약도감 육창수
  2. 오수유로부터 acetylcolinesterase 활성저해성분의 분리 및 그 작용기전 김혜자
  3. 한국의 자원식물Ⅱ 김태정
  4. 본초학 이상인
  5. 한약림상응용 이상인;안덕균;신민교
  6. 향약대사전 정보섭;신민교
  7. 중약대사전 강소신의학원
  8. 중초약학 향학 상해중의학원
  9. 현대중약약리학 왕본상
  10. 중약약리여응용 왕욕생(주편)
  11. 중약현대연구여림상응용 음건;곽력궁
  12. 도설한방의약대사전Ⅱ 진존인
  13. 중약학 안정화
  14. 상용중약성분여약리수책 황태강
  15. 병리학 이중달
  16. 한방림상학 채인식
  17. 일본약국방해설서 일본공정서협회
  18. Pathologic basis of disease Robbins,S.L.
  19. J. P. E. T. v.276 no.3 The vasorelaxing action of rutaecarpine. direct paradoxical effects on intracellular calcium concentration of vascular smooth muscle and endothelial cells Wang,G.J.;Peter,J.S.;Pang,K.T.;Yang,M.C.M.;Chow,C.J.;Chen,C.F.
  20. Eur. J. Pharmacol. v.182 The hypotensive and negative chronotropic of dehydroevodiamine Yang,M.C.M.;Wu,S.L.;Kuo,J.S.;Chen,C.F.
  21. Am. J. Chinese Medicine v.10 Hypotensive effect of dehydroevodiamine from Evodiae Fructus Xu,S.B.;Huang,Y.M.;Lau,C.N.;Wat,C.K.;Kong,Y.C.
  22. Eur. J. Pharmacol v.155 The vasorelaxant effect of evocarpine in isolated aortic strips Yamahara,J.;Kobayashi,G.;Matsuda,H.;Fujimura,H.
  23. J. Pharmacol. v.191 Hypotensive effects of dehydroevodiamine, a quinazolincocarboline alkaloid isolated from Evodiae rutaecarpa Yang,H.Y.;Li,S.Y.;Chen,C.F.
  24. Hypertension v.27 Chronic L-arginine administration attenuates cardiac hypertropy in SHR Matsuoka,H.;Nakata,M.;Kohno,K.;Koga,Y.;Nomura,G.;Toshima,H.;Imaizumi,T.
  25. Amr. J. Hypertension v.10 Role of nitric oxide in modulating the chronic renal and arterial pressure response to angiotensinⅡ Schannberg,C.;Tucker,B.;Pigg,K.;Granger,T.
  26. 오수유탕이 위액분비, 진통 및 부종에 미치는 영향 정우열
  27. 중의내과학 향항 상해중의학원
  28. 한약포제와 응용 이정원(외)
  29. Chinese drugs of plant medicine Tang,W.;Eisenbrand,G.
  30. Kor. J. Pharmacognosy v.11 Isolation of flavonoids from evodiae fructus Kang,S.S.;Um,B.H.;Kim,J.S.;Ahn,B.T.
  31. Planta Medica v.63 6-Methoxy-N-methyl-1,2,3,4-ahydro-beta-carboline from evodiae fructus Yu,L.L.;Ho,L.K.;Liao,J.F.;Chen,C.F.
  32. 오수유탕의 실험약리학적연구 오정현
  33. Br. J. Pharmacol. v.106 no.3 Effects of compatible using of fructurs Evodiae on the main chemical Loh,S.H.;Lee,A.R.;Huang,W.H.;Lin,C.I.
  34. 약리학강의 v.323 이우주
  35. Hypertension v.9 Influence of blood pressure on development of aortic medial smooth muscle hypertrophy in spontaneously hypertensive rats Owen,G.K.