Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Inducible Nitric Oxide Synthase Inhibitor form Mela azedarach var. Japonica

  • Kwon, Hak-Cheol (College of Pharmacy, Sung Kyun Kwan University) ;
  • Lee, Byeong-Gon (College of Pharmacy, Sung Kyun Kwan University) ;
  • Kim, Seung-Hee (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jung, Chil-Mann (College of Pharmacy, Sung Kyun Kwan University) ;
  • Hong, Sung-Youl (College of Life Science and Natural Resources, Sung Kyun Kwan University) ;
  • Han, Jeung-Whan (College of Pharmacy, Sung Kyun Kwan University) ;
  • Lee, Hyang-Woo (College of Pharmacy, Sung Kyun Kwan University) ;
  • Zee, Ok-Pyo (College of Pharmacy, Sung Kyun Kwan University) ;
  • Lee, Kang-Ro (College of Pharmacy, Sung Kyun Kwan University)
  • Published : 1999.08.01
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Abstract

In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two $\beta$-carboline (2) have been isolated form the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 to 2 showed marked inhibitory activity of iNOS on LPS-and interferon-${\gamma}$-stimulated RAW 264.7 cells.

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