약학회지 (YAKHAK HOEJI)

  • 제43권2호
  • /
  • Pages.214-220
  • /
  • 1999
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Carrageenin으로 흰쥐 발 염증으로 Indomethacin에 의한 유도성 nitric oxide synthase의 발현증가

Potentiation of Inducible Nitric Oxide Expression by Indomethacin in Carageenin-treated Rat Paw Inflammation

  • 원혜영 (서울대학교 약학대학) ;
  • 강건욱 (서울대학교 약학대학) ;
  • 김영미 (국립보건원 특수 질환부 대사질환과) ;
  • 김낙두 (서울대학교 약학대학)
  • 발행 : 1999.04.01
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초록

Present study was aimed to examine whether indomethacin affected the production of NO in the rat paw exudate by carrageenin. Paw edema and nitrite/nitrate levels in the paw exudate were maximal after 4 h and remained elevated up to 10 h, whereas indomethacin (10 mg/kg, po) significantly inhibited the carrageenin-induced paw edema and levels of nitrate in the paw exudate. However, paw edema and nitrite/nitrite levels were increased thereafter for 10 h. Indomethacin also enhanced the expression of iNOS mRNA and protein 4 h after carrageenin infection. Indomethacin inhibited the level of $PGE_2$ in the paw exudate in a time-dependent manner. These results suggest the possibility that indomethacin may potentiate expression of iNOS and subsequently increase nitrite/nitrate level in the late phase of carrageenin-induced rat paw inflammation possibly by suppressing cycloxygenase activity.

키워드

참고문헌

  1. J. Pharmaco. Exp. Ther. v.166 Biphasic development of carrageenin edema in rats Vinegar, R.;Schreiber, W.;Hugo, R.
  2. Proc. Natl. Acad. Sci. (USA) v.91 Inducible isoforms of cyclooxygenase and nitric oxide synthase in inflammation Vane, J. R.;Dunn, C. J.;Appleton, I.;Tomlinson, A.;Bishop-Bailey, D.;Croxtall J.;Willoughby, D. A.
  3. Br. J. Pharmacol. v.113 Cyclooxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy Tomlinson, A.;Appleton, I.;Moore, A. R.;Willis, D.;Mitchell, J. A.;Willoughby, D.
  4. Proc. Natl. Acad. Sci. (USA) v.90 Nitric oxide activates cyclooxygenase enzymes Salvemini, D.;Misko, R. P.;Masferrer, J. L.;Seibert, K.;Currie, M. G.;Needleman, P.
  5. Pharmacol. Rev. v.43 Nitric oxide: Physiology, pathophysiology, and pharmacology Moncada, S.;Palmer, R. M. J.;Higgs, E. A.
  6. Proc. Natl. Acad. Sci. (USA) v.87 Isolation of nitric oxide synthase, a calmodulin-requiring enzyme Bredt, D. S.;Snyder, S. H.
  7. Proc. Natl. Acad. Sci. (USA) v.88 Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase Pollock, J. S.;Forstermann, U.;Mitchell, J. A.;Warner, T. D.;Schmidt, H. W.;Nakane, M.;Murad, F.
  8. Proc. Natl. Acad. Sci. (USA) v.82 Mammalian nitrate biosynthesis: macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide Stuehr, D. J.;Marletta, M. A.
  9. Proc. Natl. Acad. Sci. (USA) v.87 EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages Lancaster, J. R., Jr.;Hibbs, J. B., Jr.
  10. Proc. Natl. Acad. Sci. (USA) v.87 Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide Beckman, J. S.;Beckman, T. W.;Chen, J.;Marshall, P. A.;Freeman, C. A.
  11. Science v.254 DNA deamination ability and genotoxicity of nitric oxide and its progenitors Wink, D. A;Kasprzak, K. S.;Maragos, C. M.;Elespuru, R. K.;Nisra, M.;Dunams, R. M.;Cebula, R. A.;Koch, W. H.;Andrews, A. W.;Allen, J. S.;Keefer, L. K.
  12. Biochem. Biophys. Res. Commun. v.172 Reversal of endotoxin-mediated shock by $N^G$-methyl-L-arginine, and inhibitor of nitric oxide synthesis Kilbourn, R. G.;Jubran, A.;Gross, S. S.;Griffith, O. W.;Levi, R.;Adams, J.;Lodato, R. F.
  13. Proc. Natl. Acad. Sci. (USA) v.88 A Tissue injury caused by deposition of immune complexes is L-arginine dependent Mulligan, M. S.;Hevel, J. M.;Marletta, M. A.;Ward, P.
  14. Eur. J. Pharmacol. v.211 Modulation of acute inflammation by endogenous nitrite oxide Ialenti, A.;Ianaro, A.;Moncada, S.;Di Rosa, M.
  15. FASEB J. v.1 Inflammation and the mechanisms of action of anti-inflammatory drugs Vane, J. R.;Botting, R.
  16. Drug. Dev. Res. v.25 Mitogen-inducible prostaglandin G/H synthesis; a new target for nonsteroidal antiinflammatory durgs Xie, W.;Robertson, D. L.;Simmons, D. L.
  17. J. Biol. Chem. v.263 Regulation of fibroblast cyclooxygenase synthesis by interleukin 1 Raz, A.;Wyche, A.;Needleman, P.
  18. J. Biol. Chem. v.267 LPS priming of alveloar macrophages for enhanced synthesis of eicosanoids involves induction of an novel PGH synthase O'Sullivan, G. M.;Chilton, F. H.;Huggins, E. M., Jr.;McCall, C. E.
  19. Proc. Natl. Acad. Sci. (USA) v.91 Selective inhibition of induced COX Ⅱ in vivo is antiinflammatory and nonulcerogenid Masferrer, J. L.;Zweifel, B. S.;Manning, P.;Hauser, S.;Leahy, K.;Smith, W.;Isakson, P.;Siebert, K.
  20. Proc. Natl. Acad. Sci. (USA) v.91 Pharmacological and biochemical demonstration of COX Ⅱ in inflammation and pain Seibert, K.;Zhang, Y.;Leahy, K.;Hauser, S.;Masferrer, J.;Perkins, W.;Lee, L.;Isakson, P.
  21. Nature v.231 Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs Vane, J. R.
  22. Br. J. Pharmacol. v.107 Modulation of induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774 Morotta, P.;Sautebin, L.;Di Rosa, M.
  23. Cytokine v.3 In vitro cytokine release by activated murine peritoneal macrophages: role of prostaglandins in the differential regulation of tumor necrosis factor alpha, interleukin 1 and interleukin 6 Marcinkiewicz, J.
  24. Am. J. Respi. Cell. Mol. Biol. v.6 Enhanced release of prostaglandin E2 from macrophage of rats with silicosis Mohr, C.;Davis, G. S.;Graebner, C.;Hemenway, D. R.;Gemsa, D.
  25. Immunology v.76 The prostagladin E1 analogue, misoprostol, regulates inflammatory cytokines and immune functions in vitro the natural prostaglandin E1, E2, and E3 Haynes, K. R.;Whitehouse, M. W.;Vernon-Roberts, B.
  26. Br. J. Pharmacol. v.114 Modulation by nitric oxide of prostaglandin biosynthesis in the rat Sautebin, L.;Ialenti, A.;Ianaro, A.;Di Rosa, M.
  27. Proc. Natl. Acad. Soc. (USA) v.91 Cross-talk between cyclooxygenase and nitric oxide pathways: Porstaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1 Tetsuka, T.;Daphna-Iken, D.;Srivastava, S. K.;Baier, L. D.;DuMaine, J.;Morrison, A. R.
  28. Proc. Soc. Exp. Biol. Med. v.215 Changes in inducible nitric oxide synthase expression in experimental glomerulonephritis Lianos, E. A.;Liu, J.
  29. Arthritis and Rheumatism v.9 Treatment of Adjuvant Arthritis in Rats with Anti-inflammatory Drugs Winter, C. A.;Nuss, G. W.
  30. Anal. Biochem. v.72 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Bradford, M. M.
  31. Nature v.227 Cleavage of structural proteins during assembly of the head of the bacteriophage T4 Laemmli, U. K.
  32. J. Lip.Res. v.37 Activation of LDL receptor gene expression in HepG2 cells by hepatocyte growth gactor Pak, Y. K.;Kanuck, M. P.;Berrios, K.;Briggs, M. R.;Cooper, A. D.;Ellsworth, J. L.
  33. Br. J. Pharmacol. v.110 Aminoguanidine selectively inhibits inducible nitric oxide synthase Griffiths, M. J. D.;Messent, M.;MacAllister, R. J.;Evans, T. W.
  34. Eur. J. Pharmacol. v.233 Selective inhibition of the inducible nitric oxide syntase by aminoguanidine Misko, T. P.;Moore, W. M.;Kasten, R. P.;Nickols, G. A.;Corbett, J. A.;Tilton, R. G.;McDaniel, M. L.;Williamson, J. R.;Currie, M. G.
  35. J. Immunol. v.137 Posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate Knudsen, P. J.;Dinarello, C. A.;Strom, T. B.
  36. J. Immunol. v.136 Prostaglandins as endogenous mediators of interleukin 1 production Kunkel, S. L.;Chensue, S. W.;Phan, S. H.